伊祖肽素A和B，由一种放线菌产生的新型糖肽类抗生素。

Izupeptins A and B, new glycopeptide antibiotics produced by an actinomycete.

作者信息

Spiri-Nakagawa P, Fukushi Y, Maebashi K, Imamura N, Takahashi Y, Tanaka Y, Tanaka H, Omura S

出版信息

J Antibiot (Tokyo). 1986 Dec;39(12):1719-23. doi: 10.7164/antibiotics.39.1719.

DOI:10.7164/antibiotics.39.1719

Abstract

In the course of screening for new high molecular weight peptidoglycan synthesis inhibitors, izupeptins A and B, antibiotics active against Gram-positive bacteria including methicillin-resistant Staphylococci and Clostridium were discovered. The antibiotics were found to be new members of the glycopeptide antibiotic family, namely of the vancomycin type, based on chemical and spectroscopic data. The molecular weight of izupeptin A was determined to be 1,475 by SI (secondary ion)-MS (integer molecular weight, 1,473), and it contains two chlorine atoms.

摘要

在筛选新型高分子量肽聚糖合成抑制剂的过程中，发现了伊祖肽素A和B，这两种抗生素对包括耐甲氧西林葡萄球菌和梭菌在内的革兰氏阳性菌具有活性。根据化学和光谱数据，这些抗生素被发现是糖肽类抗生素家族的新成员，即万古霉素类型。通过二次离子质谱法（SI-MS，整数分子量为1473）测定伊祖肽素A的分子量为1475，它含有两个氯原子。