Wang Kang, Lu Yan, Li Haibin, Zhang Jun, Ju Yongle, Ouyang Manzhao
Department of Gastrointestinal Surgery, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde Foshan), Shunde, Foshan, 528300, Guangdong, China.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510080, Guangdong, China.
Cancer Cell Int. 2024 Jan 6;24(1):15. doi: 10.1186/s12935-023-03194-0.
Metabolic reprogramming, which is recognized as a hallmark of cancer, refers to the phenomenon by which cancer cells change their metabolism to support their increased biosynthetic demands. Tumor cells undergo substantial alterations in metabolic pathways, such as glycolysis, oxidative phosphorylation, pentose phosphate pathway, tricarboxylic acid cycle, fatty acid metabolism, and amino acid metabolism. Latest studies have revealed that long non-coding RNAs (lncRNAs), a group of non-coding RNAs over 200 nucleotides long, mediate metabolic reprogramming in tumor cells by regulating the transcription, translation and post-translational modification of metabolic-related signaling pathways and metabolism-related enzymes through transcriptional, translational, and post-translational modifications of genes. In addition, lncRNAs are closely related to the tumor microenvironment, and they directly or indirectly affect the proliferation and migration of tumor cells, drug resistance and other processes. Here, we review the mechanisms of lncRNA-mediated regulation of glucose, lipid, amino acid metabolism and tumor immunity in gastrointestinal tumors, aiming to provide more information on effective therapeutic targets and drug molecules for gastrointestinal tumors.
代谢重编程被认为是癌症的一个标志，它指的是癌细胞改变其代谢以满足其增加的生物合成需求的现象。肿瘤细胞在代谢途径上发生了实质性改变，如糖酵解、氧化磷酸化、磷酸戊糖途径、三羧酸循环、脂肪酸代谢和氨基酸代谢。最新研究表明，长链非编码RNA（lncRNA）是一类长度超过200个核苷酸的非编码RNA，通过对基因进行转录、翻译和翻译后修饰，调控代谢相关信号通路和代谢相关酶的转录、翻译和翻译后修饰，从而介导肿瘤细胞的代谢重编程。此外，lncRNA与肿瘤微环境密切相关，它们直接或间接影响肿瘤细胞的增殖、迁移、耐药性等过程。在此，我们综述lncRNA介导的胃肠道肿瘤中葡萄糖、脂质、氨基酸代谢及肿瘤免疫调节机制，旨在为胃肠道肿瘤的有效治疗靶点和药物分子提供更多信息。
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