Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, 20850, United States.
Computing and Software Solutions for Science, LLC, Bethany Beach, DE, 19930, United States.
Radiat Prot Dosimetry. 2024 Mar 20;200(4):379-386. doi: 10.1093/rpd/ncad315.
We derived the first comprehensive organ dose library for Canadian pediatric and adult patients who underwent computed tomography (CT) scans between 1992 and 2019 to support epidemiological analysis of radiation risk. We calculated organ absorbed doses for Canadian CT patients in two steps. First, we modeled Computed Tomography Dose Index (CTDI) values by patient age, scan body part, and scan year for the scan period between 1992 and 2019 using national survey data conducted in Canada and partially the United Kingdom survey data as surrogates. Second, we converted CTDI values to organ absorbed doses using a library of organ dose conversion coefficients built in an organ dose calculation program, the National Cancer Institute dosimetry system for CT. In result, we created a library of doses delivered to 33 organs and tissues by different patient ages and genders, scan body parts and scan years. In the scan period before 2000, the organs receiving the greatest dose in the head, chest and abdomen-pelvis scans were the active marrow (3.7-15.2 mGy), lungs (54.7-62.8 mGy) and colon (54.9-68.5 mGy), respectively. We observed organ doses reduced by 24% (pediatric head and torso scans, and adult head scans) and 55% (adult torso scans) after 2000. The organ dose library will be used to analyse the risk of radiation exposure from CT scans in the Canadian CT patient cohort.
我们为在 1992 年至 2019 年间接受过计算机断层扫描 (CT) 的加拿大儿科和成年患者生成了首个全面的器官剂量库,以支持对辐射风险的流行病学分析。我们分两步计算加拿大 CT 患者的器官吸收剂量。首先,我们使用在加拿大和部分英国进行的全国调查数据作为替代,根据患者年龄、扫描部位和扫描年份来模拟 1992 年至 2019 年间的 CT 剂量指数 (CTDI) 值。其次,我们使用国家癌症研究所 CT 剂量计算程序中的器官剂量转换系数库将 CTDI 值转换为器官吸收剂量。结果,我们为不同年龄和性别的患者、扫描部位和扫描年份创建了一个剂量库,其中包含 33 个器官和组织的剂量。在 2000 年前的扫描期间,头部、胸部和腹部-骨盆扫描中接收到最大剂量的器官分别是活性骨髓(3.7-15.2mGy)、肺(54.7-62.8mGy)和结肠(54.9-68.5mGy)。我们观察到 2000 年后,儿科头部和躯干扫描以及成年头部扫描的器官剂量降低了 24%,成年躯干扫描的器官剂量降低了 55%。该器官剂量库将用于分析加拿大 CT 患者队列中 CT 扫描的辐射暴露风险。