Sharma Nitika, Singh Hari Shankar, Khanna Rajesh, Kaur Amanpreet, Agarwal Mayank
Department of Electronics and Communication Engineering, Thapar Institute of Engineering and Technology, Patiala, Punjab India.
Thapar-VT Center of Excellence in Emerging Materials (CEEMS), Thapar Institute of Engineering and Technology, Patiala, Punjab India.
Biomed Eng Lett. 2023 Jul 12;14(1):1-12. doi: 10.1007/s13534-023-00300-z. eCollection 2024 Jan.
Numerous designs and methods have been examined to improve penetration depth (PD), but there is a need for research to explore the potential increase in PD through uniform heating, a compact applicator, and low input power. This paper presents metasurface based hyperthermia lens applicator with water bolus for uniform heating of cancerous tissues. The proposed applicator consists of a stacked spiral antenna and a spiral-shaped frequency selective surface as a superstrate. The spiral antenna and superstrate are optimized on a low cost FR4 substrate having a size of 32 × 32 × 3.27mm and 10 × 10 × 1.6mm (size of the unit cell), respectively. The proposed applicator is simulated with heterogeneous phantom (skin, fat, and muscle layers) and with the Gustav voxel model with and without a water bolus layer. The number of unit cells in the superstrate is optimized to direct the maximum energy toward the tumor location. The performance study of the applicator is carried out in terms of specific absorption rate, PD, and effective field size. Further, thermal analysis is carried out with 1.9 W of input power at the antenna port, and the highest 44.7 °C temperature rise is obtained. The cancerous tissue's (tumor) surrounding temperature is between 41 and 45 °C, which is adequate for efficient hyperthermia treatment. Finally, the proposed metasurface hyperthermia lens applicator is fabricated and experimentally validated in a mimicked phantom's presence.
The online version contains supplementary material available at 10.1007/s13534-023-00300-z.
人们已经研究了许多设计和方法来提高穿透深度（PD），但仍需要开展研究，以探索通过均匀加热、紧凑的施源器和低输入功率来增加PD的可能性。本文介绍了一种基于超表面的带有水垫的热疗透镜施源器，用于癌组织的均匀加热。所提出的施源器由一个堆叠螺旋天线和一个作为覆盖层的螺旋形频率选择表面组成。螺旋天线和覆盖层分别在尺寸为32×32×3.27mm的低成本FR4基板和尺寸为10×10×1.6mm（单元尺寸）的基板上进行了优化。所提出的施源器在异质体模（皮肤、脂肪和肌肉层）以及有和没有水垫层的古斯塔夫体素模型上进行了模拟。对覆盖层中的单元数量进行了优化，以便将最大能量导向肿瘤位置。从比吸收率、PD和有效场大小方面对施源器进行了性能研究。此外，在天线端口输入1.9W功率的情况下进行了热分析，获得了最高44.7°C的温度升高。癌组织（肿瘤）周围的温度在41至45°C之间，这对于有效的热疗治疗是足够的。最后，制作了所提出的超表面热疗透镜施源器，并在模拟体模存在的情况下进行了实验验证。
在线版本包含可在10.1007/s13534-023-00300-z获取的补充材料。
