解析m5C修饰在癌症中对RNA的重要作用及机制。
Deciphering the vital roles and mechanism of m5C modification on RNA in cancers.
作者信息
Zheng Lemei, Duan Yumei, Li Mengna, Wei Jianxia, Xue Changning, Chen Shipeng, Wei Qingqing, Tang Faqing, Xiong Wei, Zhou Ming, Deng Hongyu
机构信息
NHC Key Laboratory of Carcinogenesis, Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha, Hunan, China.
Cancer Research Institute and School of Basic Medical Sciences, Central South University Changsha, Hunan, China.
出版信息
Am J Cancer Res. 2023 Dec 15;13(12):6125-6146. eCollection 2023.
5-methylcytosine (m5C modification) plays an essential role in tumors, which affects different types of RNA, the expression of downstream target genes, and downstream pathways, thus participating in the tumor process. However, the effect of m5C modification on RNA in tumors and the exact mechanism have not been systematically reviewed. Therefore, we reviewed the status and sites of m5C modification, as well as the expression pattern and biological functions of m5C regulators in tumors, and further summarized the effects and regulation mechanism of m5C modification on messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), long non-coding RNA (lncRNA) and other RNA in tumors. Finally, we summed up the interaction network, potential application, and value in clinical diagnosis and treatment of tumors. Taken together, this review benefits revealing the mechanism of m5C modification in tumor progression and provides new strategies for tumor diagnosis and treatment.
5-甲基胞嘧啶（m5C修饰）在肿瘤中发挥着重要作用，它影响不同类型的RNA、下游靶基因的表达以及下游通路，从而参与肿瘤进程。然而，m5C修饰对肿瘤中RNA的影响及确切机制尚未得到系统综述。因此，我们综述了m5C修饰的状态和位点，以及m5C调节剂在肿瘤中的表达模式和生物学功能，并进一步总结了m5C修饰对肿瘤中信使核糖核酸（mRNA）、核糖体核糖核酸（rRNA）、转运核糖核酸（tRNA）、长链非编码核糖核酸（lncRNA）和其他RNA的影响及调控机制。最后，我们总结了其相互作用网络、潜在应用以及在肿瘤临床诊断和治疗中的价值。综上所述，本综述有助于揭示m5C修饰在肿瘤进展中的机制，并为肿瘤诊断和治疗提供新策略。
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