Chen Yan, Lin Ting, Tang Le, He Lan, He Yingchun
School of Medicine, Hunan University of Chinese Medicine Changsha, Hunan, China.
Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function, Hunan University of Chinese Medicine Changsha 410208, China.
Am J Cancer Res. 2023 Dec 15;13(12):5805-5824. eCollection 2023.
Nasopharyngeal carcinoma (NPC) is a prevalent cancerous tumor that affects the head and neck region. Recent studies have provided compelling evidence indicating the significant involvement of microRNAs (miRNAs) in the development and progression of NPC. This review aims to present a comprehensive summary of the current knowledge regarding miRNA signatures in NPC, encompassing their expression patterns, molecular mechanisms, and potential therapeutic implications. Initially, the article outlines the aberrant expression of miRNAs in NPC and elucidates their roles in tumor initiation, invasion, and metastasis. Subsequently, the underlying molecular mechanisms of miRNA-mediated regulation of NPC-associated signaling pathways are discussed. Additionally, the review highlights the potential clinical applications of miRNAs as diagnostic and prognostic biomarkers, as well as their therapeutic potential in NPC treatment. In conclusion, this review underscores the critical involvement of miRNAs in NPC pathogenesis and underscores their promise as novel therapeutic targets for combating this devastating disease.
鼻咽癌（NPC）是一种影响头颈部区域的常见癌性肿瘤。最近的研究提供了令人信服的证据，表明微小RNA（miRNA）在鼻咽癌的发生和发展中起重要作用。本综述旨在全面总结目前关于鼻咽癌中miRNA特征的知识，包括它们的表达模式、分子机制和潜在的治疗意义。文章首先概述了miRNA在鼻咽癌中的异常表达，并阐明了它们在肿瘤起始、侵袭和转移中的作用。随后，讨论了miRNA介导的鼻咽癌相关信号通路调控的潜在分子机制。此外，该综述强调了miRNA作为诊断和预后生物标志物的潜在临床应用，以及它们在鼻咽癌治疗中的治疗潜力。总之，本综述强调了miRNA在鼻咽癌发病机制中的关键作用，并强调了它们作为对抗这种毁灭性疾病的新型治疗靶点的前景。
