比较基底外侧杏仁核连接组学揭示了猕猴和小鼠中向额叶皮质的可分离单神经元投射模式。

Comparative basolateral amygdala connectomics reveals dissociable single-neuron projection patterns to frontal cortex in macaques and mice.

作者信息

Zeisler Zachary R, Heslin Kelsey A, Stoll Frederic M, Hof Patrick R, Clem Roger L, Rudebeck Peter H

机构信息

Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.

Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

出版信息

bioRxiv. 2023 Dec 18:2023.12.18.571711. doi: 10.1101/2023.12.18.571711.

DOI:10.1101/2023.12.18.571711

PMID:38187599

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10769239/

Abstract

The basolateral amygdala (BLA) projects to the frontal cortex (FC) in both rodents and primates, but the comparative organization of single-neuron BLA-FC projections is unknown. Using a barcoded connectomic approach, we found that BLA neurons are more likely to project to multiple distinct parts of FC in mice than in macaques. Further, while single BLA neuron projections to nucleus accumbens are similarly organized in mice and macaques, BLA-FC connections differ.

摘要

在啮齿动物和灵长类动物中，基底外侧杏仁核（BLA）都向额叶皮质（FC）投射，但单神经元BLA-FC投射的比较组织情况尚不清楚。通过一种条形码连接组学方法，我们发现与猕猴相比，小鼠的BLA神经元更有可能投射到FC的多个不同部分。此外，虽然小鼠和猕猴中单个BLA神经元向伏隔核的投射组织方式相似，但BLA-FC连接却有所不同。