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在哺乳动物斑点试验中，12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对致癌物诱导的突变或重组的增强作用。

Enhancement of carcinogen-induced mutations or recombinations by 12-O-tetradecanoyl-phorbol-13-acetate in the mammalian spot test.

作者信息

Fahrig R

出版信息

J Cancer Res Clin Oncol. 1987;113(1):61-6. doi: 10.1007/BF00389968.

DOI:10.1007/BF00389968
PMID:3818779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12248381/
Abstract

The mammalian spot test is suitable for detecting gene mutations and reciprocal recombinations. When given alone 12-O-tetradecanoyl-phorbol-13-acetate (TPA) did not have any statistically significant effect upon these genetic alterations. In combination with ethylnitrosourea (ENU) however TPA enhanced the effect of the mutagen/carcinogen. The effective dose range of TPA + ENU was very small, i.e., between 2 X 0.2 and 2 X 0.33 mg/kg, but the effect was very strong as shown by the steep slope of the dose-effect curve. The results agree with the hypothesis that the mode of action of cocarcinogens and tumor promoters is a genetic one and that recombination plays an important role in this process.

摘要

哺乳动物斑点试验适用于检测基因突变和相互重组。单独给予12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）时，对这些基因改变没有任何统计学上的显著影响。然而，与乙基亚硝基脲（ENU）联合使用时，TPA增强了诱变剂/致癌物的作用。TPA + ENU的有效剂量范围非常小，即2×0.2至2×0.33毫克/千克之间，但剂量 - 效应曲线的陡坡表明其作用非常强烈。这些结果与以下假设一致：促癌剂和肿瘤启动子的作用模式是遗传作用模式，并且重组在这一过程中起重要作用。

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本文引用的文献

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Radiation-Induced Presumed Somatic Mutations in the House Mouse.辐射诱导的家鼠假定体细胞突变。
Genetics. 1957 Mar;42(2):161-75. doi: 10.1093/genetics/42.2.161.
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The tumour promoter TPA does not affect mutation to ouabain resistance in L5178Y mouse lymphoma cells.肿瘤启动子佛波酯不影响L5178Y小鼠淋巴瘤细胞对哇巴因抗性的突变。
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Modification of sister chromatid exchanges and radiation-induced transformation in rodent cells by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and two retinoids.肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯和两种类维生素A对啮齿动物细胞中姐妹染色单体交换及辐射诱导转化的影响
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Effects of a tumor promoter and an anti-promoter on spontaneous and UV-induced 6-thioguanine-resistant mutations and sister-chromatid exchanges in V79 Chinese hamster cells.一种肿瘤启动剂和一种抗启动剂对V79中国仓鼠细胞中自发及紫外线诱导的6-硫鸟嘌呤抗性突变和姐妹染色单体交换的影响。
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Effect of tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate on induction of sister-chromatid exchanges in Chinese hamster V79 cells treated with mutagens.肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对经诱变剂处理的中国仓鼠V79细胞中姐妹染色单体交换诱导的影响。
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The effect of non-phorbol promoters as compared with phorbol myristate acetate on sister chromatid exchange induction in cultured Chinese hamster cells.与佛波醇肉豆蔻酸酯乙酸盐相比，非佛波醇启动子对培养的中国仓鼠细胞中姐妹染色单体交换诱导的影响。
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Factors influencing the induction of sister chromatid exchanges in mammalian cells by 12-O-tetradecanoyl-phorbol-13-acetate.12-氧-十四烷酰佛波醇-13-乙酸酯对哺乳动物细胞中姐妹染色单体交换诱导作用的影响因素。
Carcinogenesis. 1981;2(7):601-7. doi: 10.1093/carcin/2.7.601.
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Investigation of the effects of the phorbol ester TPA on carcinogen-induced forward mutagenesis to 6-thioguanine-resistance in V79 Chinese hamster cells.佛波酯TPA对致癌物诱导V79中国仓鼠细胞产生6-硫鸟嘌呤抗性正向诱变作用的研究。
Carcinogenesis. 1981;2(1):43-7. doi: 10.1093/carcin/2.1.43.
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The effect of the tumour promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on UV- and MNNG-induced sister chromatid exchanges in mammalian cells.肿瘤启动子12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）对哺乳动物细胞中紫外线和N - 甲基 - N - 亚硝基胍诱导的姐妹染色单体交换的影响。
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12-O-tetradecanoylphorbol-13-acetate (TPA) induces sister-chromatid exchanges and delays in cell progression in Chinese hamster ovary and human cell lines.12-O-十四酰佛波醇-13-乙酸酯（TPA）可诱导中国仓鼠卵巢细胞系和人类细胞系中的姐妹染色单体交换并延迟细胞进程。
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