在哺乳动物斑点试验中，12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对致癌物诱导的突变或重组的增强作用。
Enhancement of carcinogen-induced mutations or recombinations by 12-O-tetradecanoyl-phorbol-13-acetate in the mammalian spot test.
作者信息
Fahrig R
出版信息
J Cancer Res Clin Oncol. 1987;113(1):61-6. doi: 10.1007/BF00389968.
Abstract
The mammalian spot test is suitable for detecting gene mutations and reciprocal recombinations. When given alone 12-O-tetradecanoyl-phorbol-13-acetate (TPA) did not have any statistically significant effect upon these genetic alterations. In combination with ethylnitrosourea (ENU) however TPA enhanced the effect of the mutagen/carcinogen. The effective dose range of TPA + ENU was very small, i.e., between 2 X 0.2 and 2 X 0.33 mg/kg, but the effect was very strong as shown by the steep slope of the dose-effect curve. The results agree with the hypothesis that the mode of action of cocarcinogens and tumor promoters is a genetic one and that recombination plays an important role in this process.
摘要
哺乳动物斑点试验适用于检测基因突变和相互重组。单独给予12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）时，对这些基因改变没有任何统计学上的显著影响。然而，与乙基亚硝基脲（ENU）联合使用时，TPA增强了诱变剂/致癌物的作用。TPA + ENU的有效剂量范围非常小，即2×0.2至2×0.33毫克/千克之间，但剂量 - 效应曲线的陡坡表明其作用非常强烈。这些结果与以下假设一致：促癌剂和肿瘤启动子的作用模式是遗传作用模式，并且重组在这一过程中起重要作用。
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