Department of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an Honghui Hospital North District, Xi'an, Shaanxi, 710000, People's Republic of China.
Int J Nanomedicine. 2024 Jan 3;19:19-34. doi: 10.2147/IJN.S442775. eCollection 2024.
Peripheral nerve injuries, arising from a diverse range of etiologies such as trauma and underlying medical conditions, pose substantial challenges in both clinical management and subsequent restoration of functional capacity. Addressing these challenges, nanoparticles have emerged as a promising therapeutic modality poised to augment the process of peripheral nerve regeneration. However, a comprehensive elucidation of the complicated mechanistic foundations responsible for the favorable effects of nanoparticle-based therapy on nerve regeneration remains imperative. This review aims to scrutinize the potential of nanoparticles as innovative therapeutic carriers for promoting peripheral nerve repair. This review encompasses an in-depth exploration of the classifications and synthesis methodologies associated with nanoparticles. Additionally, we discuss and summarize the multifaceted roles that nanoparticles play, including neuroprotection, facilitation of axonal growth, and efficient drug delivery mechanisms. Furthermore, we present essential considerations and highlight the potential synergies of integrating nanoparticles with emerging technologies. Through this comprehensive review, we highlight the indispensable role of nanoparticles in propelling advancements in peripheral nerve regeneration.
周围神经损伤源于多种病因，如创伤和潜在的医疗状况，给临床管理和随后的功能恢复带来了重大挑战。为了应对这些挑战，纳米颗粒作为一种有前途的治疗方法已经出现，有望促进周围神经再生。然而，全面阐明纳米颗粒治疗对神经再生的有利影响的复杂机制基础仍然是必要的。本综述旨在探讨纳米颗粒作为促进周围神经修复的创新治疗载体的潜力。本综述深入探讨了与纳米颗粒相关的分类和合成方法。此外，我们讨论并总结了纳米颗粒所扮演的多种角色，包括神经保护、促进轴突生长和有效的药物输送机制。此外，我们提出了必要的考虑因素，并强调了将纳米颗粒与新兴技术相结合的潜在协同作用。通过这项全面的综述，我们强调了纳米颗粒在推动周围神经再生方面的不可或缺的作用。
