Lei Pan, Ju Yixin, Peng Fenfen, Luo Jie
Hubei Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Hubei Hongshan Laboratory, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, China.
Front Cell Dev Biol. 2023 Dec 11;11:1295084. doi: 10.3389/fcell.2023.1295084. eCollection 2023.
Lung cancer is one of the most malignant diseases and a major contributor to cancer-related deaths worldwide due to the deficiency of early diagnosis and effective therapy that are of great importance for patient prognosis and quality of life. Over the past decade, the advent of clustered regularly interspaced short palindromic repeats/CRISPR associated protein (CRISPR/Cas) system has significantly propelled the progress of both fundamental research and clinical trials of lung cancer. In this review, we review the current applications of the CRISPR/Cas system in diagnosis, target identification, and treatment resistance of lung cancer. Furthermore, we summarize the development of lung cancer animal models and delivery methods based on CRISPR system, providing novel insights into clinical diagnosis and treatment strategies of lung cancer.
肺癌是最具侵袭性的疾病之一，由于早期诊断和有效治疗的缺乏，它是全球癌症相关死亡的主要原因，而早期诊断和有效治疗对患者的预后和生活质量至关重要。在过去十年中，成簇规律间隔短回文重复序列/CRISPR相关蛋白（CRISPR/Cas）系统的出现显著推动了肺癌基础研究和临床试验的进展。在这篇综述中，我们回顾了CRISPR/Cas系统在肺癌诊断、靶点识别和治疗耐药性方面的当前应用。此外，我们总结了基于CRISPR系统的肺癌动物模型和递送方法的发展，为肺癌的临床诊断和治疗策略提供了新的见解。
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