Williams Hannah, Steinhagen Randolph M
Division of Colon and Rectal Surgery, Department of Surgery, The Icahn School of Medicine at Mount Sinai, New York.
Clin Colon Rectal Surg. 2023 Feb 13;37(1):5-12. doi: 10.1055/s-0043-1762557. eCollection 2024 Jan.
While both Crohn' disease (CD) and ulcerative colitis (UC) are known to predispose patients to certain intestinal malignancies, the exact mechanism of carcinogenesis remains unknown and optimal screening guidelines have not been established. This article will explore the history of our understanding of intestinal malignancy in inflammatory bowel disease (IBD). To contextualize the medical community's difficulty in linking each condition to cancer, the first section will review the discovery of CD and UC. Next, we discuss early attempts to define IBD's relationship with small bowel adenocarcinoma and colorectal cancer. The article concludes with a review of each disease's surgical history and the ways in which certain procedures produced poor oncologic outcomes.
虽然已知克罗恩病（CD）和溃疡性结肠炎（UC）都会使患者易患某些肠道恶性肿瘤，但致癌的确切机制仍然未知，尚未确立最佳筛查指南。本文将探讨我们对炎症性肠病（IBD）中肠道恶性肿瘤认识的历史。为了说明医学界在将每种病症与癌症联系起来时所遇到的困难，第一部分将回顾CD和UC的发现。接下来，我们将讨论早期界定IBD与小肠腺癌和结直肠癌关系的尝试。本文最后回顾了每种疾病的手术史以及某些手术产生不良肿瘤学结果的方式。
