2019 年在美国路易斯安那州，现场检测和鉴定导致早期流感活动和暴发的 B/维多利亚系缺失变异病毒。
In-field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019.
机构信息
Virology, Surveillance and Diagnosis Branch, Influenza Division Centers for Disease Control and Prevention Atlanta Georgia USA.
Louisiana Department of Health Office of Public Health Laboratory Baton Rouge Louisiana USA.
出版信息
Influenza Other Respir Viruses. 2024 Jan 5;18(1):e13246. doi: 10.1111/irv.13246. eCollection 2024 Jan.
BACKGROUND
In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak.
METHOD
As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses.
RESULTS
The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR).
CONCLUSION
This work underscores the value of portable platforms for rapid, onsite pathogen characterization.
背景
2019 年，路易斯安那州卫生部门报告了一起早期乙型/维多利亚系流感（B/VIC）病毒爆发事件。
方法
由于这是一起异常大规模的爆发事件，我们部署到路易斯安那州，利用基因组学和三重实时 RT-PCR 检测方法，对三种具有不同抗原性的 B/VIC 系变体病毒进行调查。
结果
调查表明，B/VIC V1A.3 亚分支含有三个氨基酸缺失，其血凝素的抗原性与 B/科罗拉多/06/2017 疫苗病毒明显不同，是在所评估样本中循环最为普遍的病毒（实时 RT-PCR 检测的 86/88 个样本中均存在）。
结论
这项工作强调了便携平台在快速现场病原体特征描述方面的价值。
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