Ying Xiaozhang, Yu Congcong, Yang Wentao, Ye Lin, Sun Rongtai, Gu Tianyuan, Fan Shunwu, Yao Shasha
Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310016, China.
Key Laboratory of Musculoskeletal System Degeneration and Regeneration, Translational Research of Zhejiang Province, Hangzhou, Zhejiang, 310016, China.
Mater Today Bio. 2023 Dec 9;24:100901. doi: 10.1016/j.mtbio.2023.100901. eCollection 2024 Feb.
Hydrogels have been widely used in various biomedical applications, including skin regeneration and tissue repair. However, the capability of certain hydrogels to absorb exudate or blood from surrounding wounds, coupled with the challenge in their long-term storage to prevent bacterial growth, can pose limitations to their efficacy in biological applications. To address these challenges, the development of a multifunctional aloin-arginine-alginate (short for 3A) bio-patch capable of transforming into a hydrogel upon absorbing exudate or blood from neighboring wounds for cutaneous regeneration is proposed. The 3A bio-patch exhibits outstanding features, including an excellent porous structure, swelling properties, and biodegradability. These characteristics allow for the rapid absorption of wound exudates and subsequent transformation into a hydrogel that is suitable for treating skin wounds. Furthermore, the 3A bio-patch exhibits remarkable antibacterial and anti-inflammatory properties, leading to accelerated wound healing and scarless repair . This study presents a novel approach to the development of cutaneous wound dressing materials.
水凝胶已广泛应用于各种生物医学领域，包括皮肤再生和组织修复。然而，某些水凝胶吸收周围伤口渗出液或血液的能力，以及长期储存以防止细菌生长的挑战，可能会限制其在生物应用中的功效。为了应对这些挑战，我们提出开发一种多功能芦荟-精氨酸-海藻酸盐（简称3A）生物贴片，它能够在吸收邻近伤口的渗出液或血液后转变为水凝胶，用于皮肤再生。3A生物贴片具有出色的特性，包括优异的多孔结构、膨胀性能和生物降解性。这些特性使得伤口渗出液能够被快速吸收，并随后转变为适合治疗皮肤伤口的水凝胶。此外，3A生物贴片具有显著的抗菌和抗炎特性，能够加速伤口愈合和实现无瘢痕修复。本研究提出了一种开发皮肤伤口敷料材料的新方法。
