Wang Min, Li Ting, Tian Jing, Zhang Liuyang, Wang Yidan, Li Sihua, Lei Bo, Xu Peng
Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, China.
Translational Medicine Center, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, China.
ACS Nano. 2024 Jan 9;18(1):395-409. doi: 10.1021/acsnano.3c07638. Epub 2023 Dec 27.
Hydrogel wound dressings play a crucial role in promoting the healing of drug-resistant bacterially infected wounds. However, their clinical application often faces challenges such as the use of numerous components, a complicated preparation process, and insufficient biological activity. Itaconic acid, known for its excellent biological and reaction activities, has not been extensively studied for the preparation of itaconic acid-based hydrogels and their application in infected wound healing. Therefore, there is a need to develop a multifunctional single-component itaconic acid-based hydrogel that is easy to synthesize and holds promising prospects for clinical use in promoting the healing of infected wounds. In this study, we present a single-component polyitaconate-based hydrogel (PICGI) with antibacterial, anti-inflammatory, and biological activity. The PICGI hydrogel demonstrates great potential in promoting healing of infected wounds and skin regeneration. It exhibits desirable thermosensitive, injectable, and adhesive properties, as well as broad-spectrum antibacterial activity and anti-inflammatory effects. Furthermore, the PICGI hydrogel is biocompatible and significantly enhances the migration and tube formation of endothelial cells. In the case of drug-resistant bacterially infected wounds, the PICGI hydrogel effectively inhibits bacterial infection and inflammation, promotes angiogenesis, and facilitates collagen deposition, thereby accelerating the healing and regeneration of the skin. This study highlights the promising application of the PICGI hydrogel as a single-component hydrogel in tissue repair associated with bacterial infection and inflammation. Moreover, the simplicity of its components, convenient preparation process, and sufficient biological activity make the PICGI hydrogel highly suitable for promotion and clinical application.
水凝胶伤口敷料在促进耐药菌感染伤口的愈合中起着关键作用。然而，它们的临床应用常常面临诸多挑战，例如使用大量成分、制备过程复杂以及生物活性不足等问题。衣康酸以其优异的生物学和反应活性而闻名，但在基于衣康酸的水凝胶制备及其在感染伤口愈合中的应用方面尚未得到广泛研究。因此，需要开发一种易于合成且在促进感染伤口愈合方面具有临床应用前景的多功能单组分衣康酸基水凝胶。在本研究中，我们展示了一种具有抗菌、抗炎和生物活性的单组分聚衣康酸酯基水凝胶（PICGI）。PICGI水凝胶在促进感染伤口愈合和皮肤再生方面显示出巨大潜力。它具有理想的热敏性、可注射性和粘附性，以及广谱抗菌活性和抗炎作用。此外，PICGI水凝胶具有生物相容性，并能显著增强内皮细胞的迁移和管腔形成。在耐药菌感染伤口的情况下，PICGI水凝胶有效抑制细菌感染和炎症，促进血管生成，并促进胶原蛋白沉积，从而加速皮肤的愈合和再生。本研究突出了PICGI水凝胶作为单组分水凝胶在与细菌感染和炎症相关的组织修复中的应用前景。此外，其成分简单、制备过程便捷以及生物活性充分，使得PICGI水凝胶非常适合推广和临床应用。
