Stefanick M L, Williams P T, Krauss R M, Terry R B, Vranizan K M, Wood P D
J Clin Endocrinol Metab. 1987 Apr;64(4):723-9. doi: 10.1210/jcem-64-4-723.
Plasma estradiol, testosterone, and sex hormone-binding globulin (SHBG) were studied in relation to plasma lipoproteins, high density lipoprotein (HDL) subfractions, and apolipoproteins in 73 healthy but sedentary middle-aged men. Among potentially confounding variables, a strong positive association was found between estradiol levels and cigarette use, while testosterone and SHBG correlated negatively with percent body fat and alcohol intake. After adjustment for smoking, percent body fat, and alcohol, plasma estradiol levels correlated negatively with total cholesterol and low density lipoprotein cholesterol, and testosterone levels correlated positively with apolipoprotein B, while SHBG levels correlated positively with HDL2 mass and apolipoprotein A-I. SHBG was also strongly associated with the waist to hip girth ratio (WHR). Adjustment for WHR eliminated the significant associations of SHBG with triglycerides, HDL2 mass, and apolipoprotein A-I. SHBG levels and WHR may reflect tissue sensitivity and the impact of exposure to fluctuating levels of sex hormones for a period of days, or longer. These variables may provide more insight into the role of sex hormones in lipoprotein metabolism than do single samples of circulating hormones. It is also suggested that long term effects of sex hormones on adipose tissue distribution may at least partially underlie sex-related differences in lipoprotein metabolism.
在73名健康但久坐不动的中年男性中，研究了血浆雌二醇、睾酮和性激素结合球蛋白（SHBG）与血浆脂蛋白、高密度脂蛋白（HDL）亚组分及载脂蛋白之间的关系。在潜在的混杂变量中，发现雌二醇水平与吸烟之间存在强正相关，而睾酮和SHBG与体脂百分比及酒精摄入量呈负相关。在对吸烟、体脂百分比和酒精进行校正后，血浆雌二醇水平与总胆固醇和低密度脂蛋白胆固醇呈负相关，睾酮水平与载脂蛋白B呈正相关，而SHBG水平与HDL2质量和载脂蛋白A-I呈正相关。SHBG还与腰臀比（WHR）密切相关。对WHR进行校正后，消除了SHBG与甘油三酯、HDL2质量和载脂蛋白A-I之间的显著关联。SHBG水平和WHR可能反映了组织敏感性以及一段时间（数天或更长时间）内暴露于波动的性激素水平的影响。这些变量可能比单次循环激素样本更能深入了解性激素在脂蛋白代谢中的作用。还表明，性激素对脂肪组织分布的长期影响可能至少部分是脂蛋白代谢中性别相关差异的基础。
