Department of Neurology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Dongguan, Guangdong, China.
Intelligent Brain Imaging and Brain Function Laboratory (Dongguan Key Laboratory), Dongguan People's Hospital, Dongguan, Guangdong, China.
Front Endocrinol (Lausanne). 2023 Dec 20;14:1323942. doi: 10.3389/fendo.2023.1323942. eCollection 2023.
The non-ketotic hyperglycemic chorea (NKHC) was a rare complication for patients with diabetes mellitus, but not been well studied. In the present research, we aimed to investigate the clinical and imaging characteristics of NKHC and explore the potential association.
We performed a case-control study with patients diagnosed as NKHC. The patients with group of NKHC were retrospectively recruited, while the matched group were set to screened patients with diabetes mellitus but no NKHC at a 1:3 ratio. The clinical and imaging data were collected for all the participants of the two groups. Firstly, Correlation analysis was conducted to test the difference of all the variables between the NKHC group and matched group. Then, the putative associated factors for NKHC were further identified.
Eleven men and 9 women with NKHC and 60 matched participants were analyzed. The mean age of the NKHC group was 68.5 ± 14.9 years. Participants with NKHC were more likely to have a higher glycosylated hemoglobin (HbA1c) level (13 ± 2.82 vs. 10.57 ± 2.71, <0.001), and a higher frequency of renal dysfunction (estimated glomerular filtration rates <60 ml/min/1.73m) (55% vs. 20%, =0.005). Logistic regression analyses showed that both higher HbA1c and renal dysfunction were significantly correlated with NKHC.
A higher value of HbA1c and renal dysfunction may be associated with the occurrence of NKHC.
非酮症高血糖性舞蹈症（NKHC）是糖尿病患者的一种罕见并发症，但尚未得到充分研究。在本研究中，我们旨在探讨 NKHC 的临床和影像学特征，并探讨其潜在的关联。
我们进行了一项病例对照研究，纳入了诊断为 NKHC 的患者。回顾性招募 NKHC 组患者，同时以 1:3 的比例筛选出患有糖尿病但无 NKHC 的患者作为对照组。收集所有两组参与者的临床和影像学数据。首先，进行相关性分析以检验 NKHC 组和对照组之间所有变量的差异。然后，进一步确定与 NKHC 相关的潜在因素。
共分析了 11 名男性和 9 名女性 NKHC 患者和 60 名匹配的参与者。NKHC 组的平均年龄为 68.5 ± 14.9 岁。NKHC 组患者的糖化血红蛋白（HbA1c）水平更高（13 ± 2.82 与 10.57 ± 2.71，<0.001），肾功能不全（估算肾小球滤过率<60 ml/min/1.73m）的频率更高（55%与 20%，=0.005）。Logistic 回归分析显示，HbA1c 升高和肾功能不全均与 NKHC 显著相关。
HbA1c 升高和肾功能不全可能与 NKHC 的发生有关。
