Nishimura Ayumi, Kado Tomonobu, Tobe Kazuyuki
First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, JPN.
Cureus. 2024 Jan 13;16(1):e52223. doi: 10.7759/cureus.52223. eCollection 2024 Jan.
Diabetic striatopathy is a rare condition with a prevalence of less than one in 100,000. Herein, we report a case of diabetic striatopathy exacerbated by hyperglycemia and hypoglycemia, with repeated follow-up with multiple imaging studies. This case suggested that putamen neuronal loss and dysfunction, gliosis, and ischemia are associated with diabetic striatopathy pathophysiology. In addition, striatal hyperintensity on T1-weighted MRI images was more pronounced after symptom remission when evaluated several times over a short period. Therefore, clinicians should be aware that even if MRI findings are normal in the very early stages of the onset of diabetic striatopathy, repeating MRIs at intervals may reveal typical findings.
糖尿病性纹状体病是一种罕见疾病，患病率低于十万分之一。在此，我们报告一例因高血糖和低血糖加重的糖尿病性纹状体病病例，并对其进行了多次影像学研究的反复随访。该病例提示壳核神经元丢失和功能障碍、胶质增生及缺血与糖尿病性纹状体病的病理生理相关。此外，在短时间内多次评估时，症状缓解后T1加权磁共振成像（MRI）上的纹状体高信号更为明显。因此，临床医生应意识到，即使在糖尿病性纹状体病发病的极早期MRI检查结果正常，但定期重复MRI检查可能会发现典型表现。
