Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt.
Department of Chemistry, Faculty of Science, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
Mikrochim Acta. 2024 Jan 8;191(2):80. doi: 10.1007/s00604-023-06112-3.
A selective and reliable modified glassy carbon sensor, based on a 1.0% Cd zeolitic imidazole framework-67 modified glassy carbon sensor (GCS), has been developed for ultrasensitive detection of dimethyl methyl phosphonate (DMMP) in human biological fluid. The synthesis of porous nanoparticles of Cd zeolitic imidazole framework-67 (Cd ZIF-67) was carried out via the hydrothermal method. The resulting Cd ZIF-67 powder emerges with good crystallinity, a rhombic dodecahedral morphology with particle size in the range 300 ~ 500 nm, and a specific surface area of 1780 m·g. Furthermore, the fabricated sensor exhibited superior performance in the detection of DMMP with two linearity ranges of 0.02-2.0 nM and 2.0-9.0 nM and a limit of detection (LOD) of 0.06 pM. The fabricated sensor exhibited good reliability, long-term stability, and repeatability, which are favourable attributes for electroanalytical detection. In addition, the fabricated sensor displayed superior performance without significant interference during the assay of DMMP in a biological fluid (human serum sample) within two linearity ranges of 0.1-1.0 nM and 1.0-6.0 nM and a LOD of 0.03 nM.
一种基于 1.0%Cd 沸石咪唑骨架-67 修饰玻碳电极的选择性和可靠的修饰玻碳传感器已被开发出来，用于灵敏检测人体生物流体中的二甲基甲基膦酸酯（DMMP）。通过水热法合成了多孔 Cd 沸石咪唑骨架-67（Cd ZIF-67）纳米粒子。所得 Cd ZIF-67 粉末具有良好的结晶性、粒径在 300~500nm 范围内的菱十二面体形态和 1780 m·g 的比表面积。此外，所制备的传感器在 DMMP 的检测中表现出优异的性能，具有 0.02-2.0 nM 和 2.0-9.0 nM 的两个线性范围和 0.06 pM 的检测限（LOD）。所制备的传感器具有良好的可靠性、长期稳定性和可重复性，这是电分析检测的有利属性。此外，在 0.1-1.0 nM 和 1.0-6.0 nM 的两个线性范围内，在生物流体（人血清样本）中测定 DMMP 时，该传感器显示出优异的性能，没有明显的干扰，LOD 为 0.03 nM。
