长链非编码 RNA SNHG14 在胃癌中的作用：促进肿瘤细胞增殖和迁移及 CDH2 表达的机制。
The role of lncRNA SNHG14 in gastric cancer: enhancing tumor cell proliferation and migration, and mechanisms of CDH2 expression.
机构信息
Department of Gynaecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
National Clinical Research Centre for Obstetrics and Gynaecology, Cancer Biology Research Centre (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Cell Cycle. 2023 Dec-Dec;22(23-24):2522-2537. doi: 10.1080/15384101.2023.2289745. Epub 2024 Jan 9.
LncRNAs are a class of non-coding RNAs that play an important role in regulating gene expression. However, their specific molecular mechanisms in gastric carcinogenesis and metastasis need further exploration. TCGA data showed that the expression of MFGE8, which was closely related to survival, was significantly positively correlated with lncRNA SNHG14. And moreover, the results of high-throughput sequencing and qRT-PCR showed that lncRNA SNHG14 was significantly elevated in gastric cancer. Further, in vitro functional realization showed that lncRNA SNHG14 overexpression significantly increased gastric cancer's proliferation, invasion and migration. Animal experiments also showed that lncRNA SNHG14 overexpression promoted tumorigenesis and metastasis in vivo. Mechanistically, MFGE8 activates the expression of lncRNA SNHG14, which activates the cellular EMT by stabilizing CDH2. Our study suggests that lncRNA SNHG14 could be a potential target for gastric cancer therapy.
lncRNAs 是一类非编码 RNA，在调节基因表达方面发挥着重要作用。然而，它们在胃癌发生和转移中的具体分子机制仍需进一步探索。TCGA 数据显示，与生存密切相关的 MFGE8 的表达与 lncRNA SNHG14 呈显著正相关。此外，高通量测序和 qRT-PCR 的结果表明，lncRNA SNHG14 在胃癌中显著上调。进一步的体外功能实现表明，lncRNA SNHG14 的过表达显著增加了胃癌的增殖、侵袭和迁移。动物实验也表明，lncRNA SNHG14 的过表达促进了体内肿瘤的发生和转移。从机制上讲，MFGE8 激活 lncRNA SNHG14 的表达，通过稳定 CDH2 激活细胞 EMT。我们的研究表明，lncRNA SNHG14 可能是胃癌治疗的一个潜在靶点。
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