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嵌合抗原受体T细胞（CAR-T）疗法后出现继发性恶性肿瘤报告后的未解问题。

Unanswered questions following reports of secondary malignancies after CAR-T cell therapy.

作者信息

Levine Bruce L, Pasquini Marcelo C, Connolly John E, Porter David L, Gustafson Michael P, Boelens Jaap J, Horwitz Edwin M, Grupp Stephan A, Maus Marcela V, Locke Frederick L, Ciceri Fabio, Ruggeri Annalisa, Snowden John, Heslop Helen E, Mackall Crystal L, June Carl H, Sureda Anna M, Perales Miguel-Angel

机构信息

Center for Cellular Immunotherapies and Department of Pathology and Laboratory Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.

Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

出版信息

Nat Med. 2024 Feb;30(2):338-341. doi: 10.1038/s41591-023-02767-w.

DOI:10.1038/s41591-023-02767-w
PMID:38195751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11688691/
Abstract

Reports of T cell malignancies after CAR-T cell therapy should be investigated, but existing data from follow-up studies suggest a low risk compared with other cancer treatments.

摘要

嵌合抗原受体T细胞（CAR-T）疗法后T细胞恶性肿瘤的报告应予以调查，但随访研究的现有数据表明，与其他癌症治疗方法相比，其风险较低。

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本文引用的文献

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Low rate of subsequent malignant neoplasms after CD19 CAR T-cell therapy.CD19嵌合抗原受体T细胞疗法后后续恶性肿瘤发生率低。
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Long-term follow-up for the development of subsequent malignancies in patients treated with genetically modified IECs.经基因修饰的肠内分泌细胞治疗后的患者发生后续恶性肿瘤的长期随访。
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