Department of Periodontology, Gulhane Faculty of Dentistry, University of Health Sciences, Neighborhood of Emrah, Keçiören, Ankara, Turkey.
Department of Periodontology, Faculty of Dentistry, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Clin Oral Investig. 2024 Jan 10;28(1):85. doi: 10.1007/s00784-023-05477-2.
The aim of this study was to evaluate the effects of wound healing using injectable platelet-rich fibrin (IPRF) after gingivectomy and gingivoplasty.
In this clinical study, 46 systemically healthy patients with chronic inflammatory gingival enlargement were randomly treated with gingivectomy-gingivoplasty + I-PRF (n=23) or gingivectomy-gingivoplasty alone (n=23). The primary outcome was to evaluate the effect of I-PRF on wound healing over a 3-week follow-up period. Samples collected from gingival crevicular fluid (GCF) were processed using enzyme-linked immunosorbent assay (ELİSA) to measure VEGF and FGF-10 biomarkers. The surgical areas were stained with Mira-2 tone and evaluated in ImageJ. Wound healing was evaluated with Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index.
VEGF values of the control group at baseline, week 2, and week 3 were significantly higher than the test group. In weeks 2 and 3, FGF-10 values were found to be significantly higher in the control group than the test group. The amount of staining was found to be significantly higher in the control group than in the test group on days 3, 7, and 14. LTH values of the control group were significantly lower than the test group and MMS values were significantly higher than those of the test group.
I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.
Platelet concentrates such as I-PRF accelerate wound healing and contribute to the patient's comfort and quality of life. I-PRF application may have positive effects on wound healing after gingivectomy and gingivoplasty operations.
本研究旨在评估龈切除术和牙龈成形术后使用注射性富血小板纤维蛋白（IPRF）对伤口愈合的影响。
在这项临床研究中，46 名患有慢性炎症性牙龈肥大的系统性健康患者被随机分为龈切除术-牙龈成形术+ I-PRF 组（n=23）或单纯龈切除术-牙龈成形术组（n=23）。主要观察指标为在 3 周的随访期间评估 I-PRF 对伤口愈合的影响。使用酶联免疫吸附试验（ELISA）从龈沟液（GCF）中提取样本，以测量 VEGF 和 FGF-10 生物标志物。用 Mira-2 色调对手术区域进行染色，并在 ImageJ 中进行评估。使用改良曼彻斯特瘢痕（MMS）量表和兰德里、特布尔和豪利（LTH）指数评估伤口愈合情况。
对照组在基线、第 2 周和第 3 周的 VEGF 值明显高于试验组。在第 2 周和第 3 周，对照组的 FGF-10 值明显高于试验组。第 3、7 和 14 天，对照组的染色量明显高于试验组。对照组的 LTH 值明显低于试验组，MMS 值明显高于试验组。
IPRF 应用对龈切除术和牙龈成形术后的上皮伤口愈合有积极影响。
血小板浓缩物如 I-PRF 可加速伤口愈合，有助于提高患者的舒适度和生活质量。IPRF 应用可能对龈切除术和牙龈成形术后的伤口愈合有积极影响。
