从 中分离得到具有强 DPPH 自由基清除活性的新咖啡酰衍生物。
New caffeoyl derivatives with potent DPPH radical scavenging activity from .
机构信息
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
出版信息
J Asian Nat Prod Res. 2024 Jan;26(1):26-37. doi: 10.1080/10286020.2023.2294066. Epub 2024 Jan 9.
Eight new caffeoyl derivatives, elephantomentosides A-H (-), together with ten known ones (-), were isolated from the whole plant of L. Their structures were elucidated using detailed spectroscopic analysis. Structurally, compounds - are composed of -D-glucopyranose, and almost all of the substituent positions are at the C-1' and C-4' of glucopyranose. The anti-inflammatory and antioxidant activities of all isolated compounds were evaluated . Compounds , , and exhibited significant DPPH scavenging capacity with IC values in the range of 10.01-25.07 M, in comparison with Vc (IC, 17.98 M).
从全株 L. 中分离得到了 8 个新的咖啡酰衍生物（elephantomentosides A-H）和 10 个已知化合物。通过详细的光谱分析阐明了它们的结构。结构上，化合物-由-β-D-吡喃葡萄糖组成，几乎所有的取代基位置都在吡喃葡萄糖的 C-1'和 C-4'。所有分离得到的化合物均具有抗炎和抗氧化活性。化合物-、-和-表现出显著的 DPPH 清除能力，IC 值范围为 10.01-25.07μM，与 Vc（IC，17.98μM）相比。
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