Shrenker P, Bartke A
J Endocrinol. 1987 Feb;112(2):221-8. doi: 10.1677/joe.0.1120221.
In the male rat, hyperprolactinaemia is associated with significant reductions in plasma LH and FSH levels and in several measures of copulatory behaviour. In contrast to this situation, experimental induction of hyperprolactinaemia in male mice and hamsters is associated with an increase in plasma gonadotrophin levels. It was therefore of interest to determine the effects of hyperprolactinaemia on the copulatory behaviour of these animals. Hyperprolactinaemia was induced by transplantation of pituitaries from adult females and sexual behaviour was tested in the presence of ovariectomized, oestrogen- and progesterone-treated females. Because hyperprolactinaemia increases plasma testosterone levels in intact male hamsters, the animals were castrated and implanted with testosterone-filled silicone elastomer capsules before induction of hyperprolactinaemia. In mice of two inbred strains, DBA/2J and C57BL/6Bg, hyperprolactinaemia appeared to stimulate male sexual behaviour as shown by a significant increase in the proportion of animals mating (C57BL/6) and a significant decrease in mount (DBA/2J) and intromission (C57BL/6Bg and DBA/2J) latencies. Similarly, hyperprolactinaemia did not suppress male copulatory behaviour in the hamster. In contrast, in two experiments in which the animals were tested three times for sexual behaviour, mount or intromission latencies were significantly reduced in pituitary-grafted, as compared with sham-operated males, in the first of the tests. Thus, in the mouse and the golden hamster, experimentally induced chronic hyperprolactinaemia stimulates both gonadotrophin release and male copulatory behaviour. These observations, together with the association of suppressive effects of hyperprolactinaemia on plasma LH and FSH levels and on sexual behaviour in the male rat, suggest the possible existence of a common mechanism underlying both endocrine and behavioural effects of hyperprolactinaemia.(ABSTRACT TRUNCATED AT 250 WORDS)
在雄性大鼠中，高催乳素血症与血浆促黄体生成素（LH）和促卵泡生成素（FSH）水平显著降低以及多种交配行为指标下降有关。与此情况相反，在雄性小鼠和仓鼠中实验性诱导高催乳素血症则与血浆促性腺激素水平升高有关。因此，确定高催乳素血症对这些动物交配行为的影响很有意义。通过移植成年雌性动物的垂体诱导高催乳素血症，并在去卵巢、接受雌激素和孕酮处理的雌性动物存在的情况下测试性行为。由于高催乳素血症会增加完整雄性仓鼠的血浆睾酮水平，所以在诱导高催乳素血症之前，先将动物阉割并植入填充睾酮的硅橡胶弹性体胶囊。在两个近交系小鼠DBA/2J和C57BL/6Bg中，高催乳素血症似乎刺激了雄性性行为，表现为交配动物比例显著增加（C57BL/6）以及爬跨潜伏期（DBA/2J）和插入潜伏期（C57BL/6Bg和DBA/2J）显著缩短。同样，高催乳素血症并未抑制仓鼠的雄性交配行为。相反，在两项对动物进行三次性行为测试的实验中，与假手术雄性相比，垂体移植雄性在第一次测试中的爬跨或插入潜伏期显著缩短。因此，在小鼠和金黄仓鼠中，实验性诱导的慢性高催乳素血症会刺激促性腺激素释放和雄性交配行为。这些观察结果，连同高催乳素血症对雄性大鼠血浆LH和FSH水平以及性行为的抑制作用，提示高催乳素血症的内分泌和行为效应可能存在共同机制。（摘要截选至250词）
