Weber R F, Ooms M P, Vreeburg J T
J Endocrinol. 1982 May;93(2):223-9. doi: 10.1677/joe.0.0930223.
The effect of the transplantable prolactin- and ACTH-secreting tumour 7315a on male copulatory behaviour was investigated. Castrated tumour-bearing rats implanted with testosterone-filled capsules exhibited significantly longer latencies to first mount or intromission and to ejaculation than castrated control animals. In contrast to the number of intromissions, the number of mount before ejaculation of the tumour-bearing rats was considerably increased. However, when castration was carried out in addition to adrenalectomy, the differences in copulatory behaviour between tumour-bearing rats and control rats were no longer present. During the last tests for copulatory behaviour the tumour-bearing rats had serum prolactin concentrations or more than 4000 ng/Ml while control rats had less than 100 ng/ml. Plasma testosterone levels produced by silicone elastomer capsules were neither affected by the presence of the tumour nor by adrenalectomy. It was concluded that hyperprolactinaemia does not suppress the copulatory behaviour of adrenalectomized rats.
研究了可移植的分泌催乳素和促肾上腺皮质激素的肿瘤7315a对雄性交配行为的影响。植入填充睾酮胶囊的去势荷瘤大鼠首次爬跨、插入或射精的潜伏期明显长于去势对照动物。与插入次数相比，荷瘤大鼠射精前的爬跨次数显著增加。然而，当除肾上腺切除外还进行去势时，荷瘤大鼠和对照大鼠之间的交配行为差异不再存在。在最后一次交配行为测试期间，荷瘤大鼠的血清催乳素浓度超过4000 ng/Ml，而对照大鼠则低于100 ng/ml。硅胶弹性体胶囊产生的血浆睾酮水平既不受肿瘤存在的影响，也不受肾上腺切除的影响。得出的结论是，高催乳素血症不会抑制肾上腺切除大鼠的交配行为。
