Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hunan key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.
Int J Dermatol. 2024 Mar;63(3):337-344. doi: 10.1111/ijd.16946. Epub 2024 Jan 10.
Rosacea is a chronic inflammatory skin disease. The diagnosis is based on the symptoms and physical signs, which still lacks objective laboratory tests or imaging tests.
To propose and evaluate the upper eyelid network pattern in rosacea.
Participants included patients diagnosed with rosacea, other facial erythematous skin diseases, and normal controls, all of whom underwent full-face imaging utilizing the VISIA® system software. According to these images, researchers evaluated the condition of the upper eyelid vascular network, developed the grading scale and then compared the difference of distribution in the three groups.
The occurrence rate of upper eyelid vascular network in rosacea was significantly higher than that in other facial erythematous skin diseases (84.3 vs. 32.0%, P < 0.001) and normal controls (84.3 vs. 28.0%, P < 0.001). The upper eyelid vascular network pattern was proposed (none [no clearly reticular vessels], mild [10-50% area of reticular vessels], moderate-to-severe [>50% area of reticular vessels]). Moderate-to-severe grade was defined as well-defined upper eyelid vascular network pattern, which was specific to patients with rosacea (rosacea vs. other facial erythematous skin diseases, adjusted odds ratio [aOR] = 5.814, 95% confidence interval [CI]: 3.899-8.670) (rosacea vs. heathy controls, aOR = 12.628, 95% CI: 8.334-19.112). The severity of the well-defined pattern had no significant association with age, duration, and phenotypes of rosacea (P > 0.05).
The well-defined upper eyelid vascular network pattern specifically appeared in patients with rosacea, which could be a possible clue to the diagnosis of rosacea.
酒渣鼻是一种慢性炎症性皮肤疾病。其诊断基于症状和体征，但目前仍缺乏客观的实验室或影像学检查。
提出并评估酒渣鼻的上眼睑网络模式。
纳入酒渣鼻患者、其他面部红斑性皮肤病患者和健康对照者，所有参与者均使用 VISIA®系统软件进行全面部成像。根据这些图像，研究人员评估上眼睑血管网络状况，制定分级量表，然后比较三组之间的分布差异。
酒渣鼻患者的上眼睑血管网络发生率明显高于其他面部红斑性皮肤病（84.3%比 32.0%，P<0.001）和健康对照者（84.3%比 28.0%，P<0.001）。提出了上眼睑血管网络模式（无[无明显网状血管]、轻度[10%-50%区域有网状血管]、中重度[>50%区域有网状血管]）。中重度等级定义为明确的上眼睑血管网络模式，这是酒渣鼻患者特有的（酒渣鼻比其他面部红斑性皮肤病，调整后的优势比[aOR]为 5.814，95%置信区间[CI]为 3.899-8.670）（酒渣鼻比健康对照者，aOR 为 12.628，95%CI 为 8.334-19.112）。明确模式的严重程度与年龄、病程和酒渣鼻表型无显著相关性（P>0.05）。
明确的上眼睑血管网络模式特异性出现在酒渣鼻患者中，这可能是酒渣鼻诊断的一个可能线索。
