Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Nanomedicine (Lond). 2024 Jan;19(1):59-77. doi: 10.2217/nnm-2023-0271. Epub 2024 Jan 10.
Sentinel lymph node (SLN) detection and biopsy is a critical staging component for several cancers. Apart from established methods using dyes or radiolabeled colloids, newer techniques are emerging, like near-infrared fluorescent compounds, targeted molecular radiopharmaceuticals and magnetic nano-tracers. In the overview section of this review, we categorize SLN detection tracers based on their principle of use. We discuss the merits of existing tracers and provide a glimpse of in-development formulations. A subsequent clinical section explores the expanded role of SLN detection in management of various cancers, citing current medical guidelines and the leading conclusions of long-term clinical trials. The concluding section tries to provide a perspective of promising developments and the work required to bring them to clinical fruition.
前哨淋巴结（SLN）检测和活检是几种癌症的关键分期组成部分。除了使用染料或放射性胶体的既定方法外，新的技术也在不断涌现，如近红外荧光化合物、靶向分子放射性药物和磁性纳米示踪剂。在本综述的概述部分，我们根据 SLN 检测示踪剂的使用原理对其进行分类。我们讨论了现有示踪剂的优点，并介绍了正在开发中的制剂。随后的临床部分探讨了 SLN 检测在各种癌症管理中的扩展作用，引用了当前的医学指南和长期临床试验的主要结论。结论部分试图提供有前途的发展的视角以及将这些发展转化为临床成果所需的工作。
