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严重创伤性脑损伤后的强迫症。

Obsessive-compulsive disorder following severe traumatic brain injury.

机构信息

Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.

Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada.

出版信息

BMJ Case Rep. 2024 Jan 9;17(1):e256834. doi: 10.1136/bcr-2023-256834.

DOI:10.1136/bcr-2023-256834
PMID:38199653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10806976/
Abstract

Obsessive-compulsive disorder (OCD) as a consequence of severe traumatic brain injury (TBI) has been reported in a limited number of case studies. Informed by CARE guidelines, we present the case of a boy in his late adolescence who sustained a severe TBI from a motor vehicle crash. His injuries required a prolonged stay in the hospital, including 3 weeks in the intensive care unit and a craniotomy to evacuate a large subdural haematoma. Obsessive-compulsive behaviours were first observed on discharge from the hospital and became worse over time. Compulsive behaviours were considered in light of a neuropsychological examination, and a diagnosis of OCD was attained. Sertraline was prescribed and effectively reduced the severity of OCD symptoms. Given the challenges comorbid conditions can pose to neurorehabilitation, a better understanding of patterns in OCD symptoms and brain lesions among reported cases will help guide the diagnosis of OCD among individuals with severe TBI.

摘要

强迫症(OCD)作为严重创伤性脑损伤(TBI)的后果,在有限数量的病例研究中有所报道。根据 CARE 指南,我们报告了一例青少年男孩,他因机动车事故导致严重的 TBI。他的伤势需要长时间住院治疗,包括在重症监护病房住院 3 周和开颅手术以清除大的硬膜下血肿。在出院时首次观察到强迫症行为,随着时间的推移病情恶化。强迫症行为是根据神经心理学检查考虑的,并获得了 OCD 的诊断。开了舍曲林,有效地减轻了 OCD 症状的严重程度。鉴于共病情况可能给神经康复带来的挑战,更好地了解报告病例中的 OCD 症状和脑损伤模式将有助于指导严重 TBI 患者 OCD 的诊断。

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本文引用的文献

1
Rehabilitation definition for research purposes. A global stakeholders' initiative by Cochrane Rehabilitation.用于研究目的的康复定义。Cochrane康复组织发起的全球利益相关者倡议。
Eur J Phys Rehabil Med. 2022 Jun;58(3):333-341. doi: 10.23736/S1973-9087.22.07509-8. Epub 2022 Mar 21.
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Mindfulness-based exposure and response prevention for obsessive compulsive disorder: Findings from a pilot randomised controlled trial.基于正念的暴露和反应预防治疗强迫症:一项初步随机对照试验的结果。
J Anxiety Disord. 2018 Jun;57:39-47. doi: 10.1016/j.janxdis.2018.04.007. Epub 2018 Apr 30.
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Association between cognitive impairments and obsessive-compulsive spectrum presentations following traumatic brain injury.创伤性脑损伤后认知障碍与强迫谱系表现之间的关联
Neuropsychol Rehabil. 2019 Mar;29(2):214-231. doi: 10.1080/09602011.2016.1272469. Epub 2017 Jan 2.
4
Systematic review of environmental risk factors for Obsessive-Compulsive Disorder: A proposed roadmap from association to causation.强迫症环境风险因素的系统评价:从关联到因果关系的拟议路线图。
Neurosci Biobehav Rev. 2016 Jun;65:36-62. doi: 10.1016/j.neubiorev.2016.03.011. Epub 2016 Mar 21.
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What do we know about obsessive-compulsive disorder following traumatic brain injury?创伤性脑损伤后强迫症我们了解多少?
CNS Spectr. 2015 Oct;20(5):463-5. doi: 10.1017/S109285291500053X. Epub 2015 Aug 28.
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Structural and functional changes of the cingulate gyrus following traumatic brain injury: relation to attention and executive skills.胼胝体损伤后扣带回的结构和功能变化:与注意力和执行技能的关系。
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Neurorehabilitation and cognitive-behaviour therapy of anxiety disorders after brain injury: An overview and a case illustration of obsessive-compulsive disorder.脑损伤后焦虑障碍的神经康复和认知行为治疗:强迫症概述及病例举例。
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New onset obsessive-compulsive symptoms in children and adolescents with severe traumatic brain injury.患有严重创伤性脑损伤的儿童和青少年出现的新发强迫症状
Depress Anxiety. 2008;25(5):398-407. doi: 10.1002/da.20398.