Department of Botany, Jangipur College, University of Kalyani, West Bengal, India.
Department of Cell and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Trends Plant Sci. 2024 Jun;29(6):681-693. doi: 10.1016/j.tplants.2023.11.021. Epub 2024 Jan 9.
Land plants have evolved with a complex mechanism of water uptake facilitated by the activity of aquaporins under normal and challenging environments. However, we lack a clear understanding of its interactions with reactive oxygen species, particularly hydrogen peroxide (HO) and the gasotransmitters nitric oxide (NO) and hydrogen sulfide (HS), under oxidative stress. Here, we assess the crosstalk of aquaporin function, HO homeostasis, and NO-HS signaling in plants and provide a computational prediction of cysteine-based oxidative post-translational modifications (oxiPTMs) in plant aquaporins. We propose that aquaporin activity could be regulated by three major oxiPTMs, S-nitrosation, S-sulfenylation, and persulfidation, mediated by NO, HO, and HS, respectively. Therefore, aquaporins might be key players in the gasotransmitter-mediated long-distance oxidative stress signals in plant cells.
陆生植物在正常和胁迫环境下，通过水通道蛋白的活性进化出了一种复杂的吸水机制。然而，我们对其与活性氧（特别是过氧化氢（HO）和气体信号分子一氧化氮（NO）和硫化氢（HS））在氧化胁迫下的相互作用缺乏清晰的认识。在这里，我们评估了水通道蛋白功能、HO 稳态和植物中 NO-HS 信号转导的串扰，并对植物水通道蛋白中基于半胱氨酸的氧化翻译后修饰（oxiPTMs）进行了计算预测。我们提出，水通道蛋白的活性可能分别受 NO、HO 和 HS 介导的 S-亚硝化、S-亚磺化和过硫化三种主要的 oxiPTMs 调节。因此，水通道蛋白可能是植物细胞中气体信号分子介导的长距离氧化应激信号的关键参与者。
