Fonseca Frederico, Forrester Mario, Advinha Ana Margarida, Coutinho Adriana, Landeira Nuno, Pereira Maria
Pharmaceutical Services, Hospital do Espírito Santo, 7000-811 Évora, Portugal.
Sociedade Portuguesa dos Farmacêuticos dos Cuidados de Saúde, 3030-320 Coimbra, Portugal.
Healthcare (Basel). 2023 Dec 29;12(1):76. doi: 10.3390/healthcare12010076.
infection (CDI) is the main source of healthcare and antibiotic-associated diarrhea in hospital context and long-term care units, showing significant morbidity and mortality. This study aimed to analyze the epidemiological context, describing the severity and outcomes of this event in patients admitted to our hospital, thus confirming the changing global epidemiological trends in comparison with other cohorts. We conducted a single-center, observational, and retrospective study at the Hospital do Espírito Santo (HESE), Évora, in Portugal, analyzing the incidence of CDI in patients meeting eligibility criteria from January to December 2018. During this period, an annual incidence rate of 20.7 cases per 10,000 patients was documented. The studied population average age was 76.4 ± 12.9 years, 83.3% over 65. Most episodes were healthcare-acquired, all occurring in patients presenting multiple risk factors, with recent antibiotic consumption being the most common. Regarding severity, 23.3% of cases were classified as severe episodes. Recurrences affected 16.7% of participants, predominantly female patients over 80 years old, all of whom were healthcare-acquired. Mortality rate was disproportionately high among the older population. Our investigation documented an overall incidence rate of over 10.4-fold the number of cases identified in the year 2000 at the same hospital, more recently and drastically, in community-associated episodes.
艰难梭菌感染（CDI）是医院环境和长期护理机构中医疗保健及抗生素相关性腹泻的主要来源，具有显著的发病率和死亡率。本研究旨在分析流行病学背景，描述我院收治患者中该事件的严重程度和结局，从而与其他队列相比确认全球流行病学趋势的变化。我们在葡萄牙埃武拉的圣灵医院（HESE）进行了一项单中心、观察性和回顾性研究，分析了2018年1月至12月符合入选标准患者的CDI发病率。在此期间，记录的年发病率为每10000名患者20.7例。研究人群的平均年龄为76.4±12.9岁，83.3%的患者年龄超过65岁。大多数病例是医疗保健获得性的，均发生在存在多种危险因素的患者中，近期使用抗生素是最常见的因素。关于严重程度，23.3%的病例被归类为严重发作。复发影响了16.7%的参与者，主要是80岁以上的女性患者，所有这些都是医疗保健获得性的。老年人群的死亡率过高。我们的调查记录的总体发病率比2000年同一医院确诊病例数高出10.4倍以上，最近在社区相关性发作中更是急剧上升。
