Gladstone Institute of Virology, Gladstone Institutes, 1650 Owens St., San Francisco, CA 941578, USA.
Department of Transfusion Medicine and Cell Therapy, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake, Toyoake 470-1192, Aichi, Japan.
Cells. 2023 Dec 28;13(1):64. doi: 10.3390/cells13010064.
The treatment of human immunodeficiency virus (HIV-1) has evolved since the establishment of combination antiretroviral therapy (ART) in the 1990s, providing HIV-infected individuals with approaches that suppress viral replication, prevent acquired immunodeficiency syndrome (AIDS) throughout their lifetime with continuous therapy, and halt HIV transmission. However, despite the success of these regimens, the global HIV epidemic persists, prompting a comprehensive exploration of potential strategies for an HIV cure. Here, we offer a consolidated overview of cell-based therapies for HIV-1, focusing on CAR-T cell approaches, gene editing, and immune modulation. Persistent challenges, including CAR-T cell susceptibility to HIV infection, stability, and viral reservoir control, underscore the need for continued research. This review synthesizes current knowledge, highlighting the potential of cellular therapies to address persistent challenges in the pursuit of an HIV cure.
自 20 世纪 90 年代联合抗逆转录病毒疗法（ART）确立以来，人类免疫缺陷病毒（HIV-1）的治疗方法不断发展，为感染 HIV 的个体提供了抑制病毒复制的方法，通过持续治疗预防终身获得性免疫缺陷综合征（AIDS），并阻止 HIV 传播。然而，尽管这些方案取得了成功，但全球 HIV 流行仍在继续，这促使人们全面探索 HIV 治愈的潜在策略。在这里，我们综合了 HIV-1 的基于细胞的治疗方法，重点介绍了 CAR-T 细胞方法、基因编辑和免疫调节。持续存在的挑战，包括 CAR-T 细胞易感染 HIV、稳定性和病毒库控制，突显了继续研究的必要性。本综述综合了当前的知识，强调了细胞疗法在解决 HIV 治愈中持续存在的挑战方面的潜力。
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