Guldhammer Cathrine Silberg, Vásquez Juan Luis, Kristensen Vibeke Møllegaard, Norus Thomas, Nadler Naomi, Jensen Jørgen Bjerggaard, Azawi Nessn
Department of Urology, Zealand University Hospital, Sygehusvej 10, 4000 Roskilde, Denmark.
Department of Clinical Medicine, University of Copenhagen, Noerregade 10, 1165 Copenhagen, Denmark.
Cancers (Basel). 2023 Dec 28;16(1):160. doi: 10.3390/cancers16010160.
Bladder cancer ranks as the 10th most common cancer globally. The diagnosis of bladder tumors typically involves cystoscopy.
This study aimed to evaluate the sensitivity and specificity of cystoscopy in detecting bladder tumors within a surveillance program following a bladder cancer diagnosis.
DESIGN, SETTING, AND PARTICIPANTS: This study utilized recordings of cystoscopies conducted at the Department of Urology, Zealand University Hospital, between July 2021 and November 2022. Clinical observations were cross-referenced with pathological results or follow-up cystoscopies. Clinically negative cystoscopies were further scrutinized for potential overlooked tumors.
Sensitivity and specificity of cystoscopy were assessed through ROC curve analysis.
A total of 565 cystoscopies were recorded, with 135 indicating clinical positivity. Among 181 cystoscopies with clinically negative results that underwent a follow-up cystoscopy, 17 patients (9.4%) were subsequently diagnosed with bladder cancer, with the lesions identified in the initial cystoscopy. The sensitivity and specificity of cystoscopy in these cases were 81% and 73%, respectively.
This trial underscores the underdiagnosis and undertreatment of bladder tumors within the current surveillance program. Additionally, aggressive malignant lesions may be overlooked, heightening the risk of disease progression. Therefore, it is recommended that cystoscopies be complemented by other diagnostic methods to ensure accurate diagnosis and proper patient treatment.
This study involved 316 patients who underwent video-recorded cystoscopies and subsequent follow-up. Of these patients, 181 initially exhibited no clinical signs of bladder cancer. However, upon reviewing the recorded cystoscopy, bladder cancer was identified in 17 patients (9.4%).
膀胱癌是全球第10大常见癌症。膀胱肿瘤的诊断通常需要进行膀胱镜检查。
本研究旨在评估膀胱镜检查在膀胱癌诊断后的监测计划中检测膀胱肿瘤的敏感性和特异性。
设计、地点和参与者：本研究利用了2021年7月至2022年11月在西兰大学医院泌尿外科进行的膀胱镜检查记录。临床观察结果与病理结果或后续膀胱镜检查结果进行了交叉对照。对临床检查结果为阴性的膀胱镜检查进行了进一步检查，以寻找可能被忽视的肿瘤。
通过ROC曲线分析评估膀胱镜检查的敏感性和特异性。
共记录了565次膀胱镜检查，其中135次显示临床阳性。在181例临床检查结果为阴性且接受了后续膀胱镜检查的病例中，有17例患者（9.4%）随后被诊断为膀胱癌，病变在初次膀胱镜检查中被发现。在这些病例中，膀胱镜检查的敏感性和特异性分别为81%和73%。
该试验强调了当前监测计划中膀胱肿瘤的诊断不足和治疗不足。此外，侵袭性恶性病变可能被忽视，增加了疾病进展的风险。因此，建议膀胱镜检查辅以其他诊断方法，以确保准确诊断和患者的合理治疗。
本研究涉及316例接受了视频记录的膀胱镜检查及后续随访的患者。在这些患者中，181例最初没有膀胱癌的临床症状。然而，在查看记录的膀胱镜检查时，在17例患者（9.4%）中发现了膀胱癌。
