Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece.
Nutrients. 2023 Dec 19;16(1):2. doi: 10.3390/nu16010002.
Breast cancer is the most frequent type of cancer in women. Oncogenic transcription factors promote the overproduction of cellular adhesion molecules and inflammatory cytokines during cancer development. Cancer cells exhibit significant upregulation of antiapoptotic proteins, resulting in increased cell survival, tumor growth, and metastasis. Research on the cell cycle-mediated apoptosis pathway for drug discovery and therapy has shown promising results. In fact, dietary phytoconstituents have been extensively researched for anticancer activity, providing indirect protection by activating endogenous defense systems. The role of polyphenols in key cancer signaling pathways could shed light on the underlying mechanisms of action. For instance, Rosmarinic Acid, a polyphenol constituent of many culinary herbs, has shown potent chemoprotective properties. In this review, we present recent progress in the investigation of natural products as potent anticancer agents, with a focus on the effect of Rosmarinic Acid on triple-negative BC cell lines resistant to hormone therapy. We highlight a variety of integrated chemical biology approaches aimed at utilizing relevant mechanisms of action that could lead to significant clinical advances in BC treatment.
乳腺癌是女性最常见的癌症类型。致癌转录因子在癌症发展过程中促进细胞黏附分子和炎症细胞因子的过度产生。癌细胞显著地上调抗凋亡蛋白，导致细胞存活、肿瘤生长和转移增加。研究细胞周期介导的凋亡途径用于药物发现和治疗已显示出有希望的结果。事实上，人们广泛研究了膳食植物成分的抗癌活性，通过激活内源性防御系统提供间接保护。多酚在关键癌症信号通路中的作用可以揭示其作用机制。例如，迷迭香酸是许多烹饪香草的多酚成分，具有很强的化学保护特性。在这篇综述中，我们介绍了天然产物作为有效抗癌剂的研究进展，重点介绍了迷迭香酸对激素治疗耐药的三阴性乳腺癌细胞系的影响。我们强调了各种综合化学生物学方法，旨在利用相关的作用机制，这可能会在乳腺癌治疗方面取得重大的临床进展。
