Carmona Loreto, Aurrecoechea Elena, García de Yébenes María Jesús
Instituto de Salud Musculoesquelética, 28045 Madrid, Spain.
Rheumatology Department, Hospital Sierrallana, Instituto de Investigación Valdecilla (IDIVAL), 39300 Torrelavega, Spain.
J Clin Med. 2023 Dec 21;13(1):55. doi: 10.3390/jcm13010055.
Rheumatoid arthritis (RA) occurs more frequently in women than in men, and the studies that have addressed clinical and prognostic differences between the sexes are scarce and have contradictory results and methodological problems. The present work aims to evaluate sex- and gender-related differences in the clinical expression and prognosis of RA as well as on the impact on psychosocial variables, coping behavior, and healthcare use and access. By identifying between sex differences and gender-related outcomes in RA, it may be possible to design tailored therapeutic strategies that consider the differences and unmet needs. Being that sex, together with age, is the most relevant biomarker and health determinant, a so-called personalized medicine approach to RA must include clear guidance on what to do in case of differences.
类风湿关节炎（RA）在女性中的发病率高于男性，而针对两性之间临床和预后差异的研究较少，且结果相互矛盾，还存在方法学问题。本研究旨在评估RA临床表型和预后方面与性别及社会性别相关的差异，以及对心理社会变量、应对行为、医疗保健利用和可及性的影响。通过识别RA中的性别差异和与社会性别相关的结果，或许有可能设计出考虑到这些差异和未满足需求的针对性治疗策略。由于性别与年龄一样，是最相关的生物标志物和健康决定因素，一种所谓的RA个性化医疗方法必须包括在出现差异时该如何做的明确指导。
