Hu Zhiqiang, Liu Zongchao, Li Wenqing, You Weicheng, Pan Kaifeng
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Chin J Cancer Res. 2023 Dec 30;35(6):595-605. doi: 10.21147/j.issn.1000-9604.2023.06.04.
Gastric cancer is a global public health burden, nearly one million new cases are diagnosed per year worldwide, of which 44% of cases occur in China. The prognosis of gastric cancer varies remarkably by the stage of cancer, and most of the patients in China are diagnosed at advanced stages, resulting in poor prognoses. Effective strategies to reduce the burden of gastric cancer include primary prevention through testing and treatment of () and secondary prevention by screening and early detection. Although many countries have issued management guidelines and consensus reports concerning these strategies, the limited availability of healthcare resources often precludes their widespread implementation. Therefore, assessing the costs, benefits, and harms of population-based intervention measures through health economic evaluation is necessary for informed health policy decisions. Accordingly, we synthesize management approaches from different countries on eradication and endoscopic screening, and also summarize recent advancements in health economic evaluations on population-based preventive strategies. The goal of the review is to provide empirical evidence supporting optimal resource allocation, maximizing benefits for the population, and ultimately reducing the burden of gastric cancer.
胃癌是一项全球性的公共卫生负担，全球每年有近100万新病例被确诊，其中44%的病例发生在中国。胃癌的预后因癌症分期不同而有显著差异，中国大多数患者在晚期才被确诊，导致预后较差。减轻胃癌负担的有效策略包括通过检测和治疗（）进行一级预防，以及通过筛查和早期发现进行二级预防。尽管许多国家已经发布了关于这些策略的管理指南和共识报告，但医疗资源的有限可用性往往妨碍了它们的广泛实施。因此，通过卫生经济评估来评估基于人群的干预措施的成本、效益和危害，对于做出明智的卫生政策决策是必要的。相应地，我们综合了不同国家关于根除和内镜筛查的管理方法，并总结了基于人群的预防策略的卫生经济评估的最新进展。本综述的目的是提供实证证据，支持优化资源配置，使人群利益最大化，并最终减轻胃癌负担。
