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通过……的染色体水平基因组组装洞察染色体和重要性状的适应性进化

Insights into the adaptive evolution of chromosome and essential traits through chromosome-level genome assembly of .

作者信息

Wang Yinwei, Yue Youxia, Li Chao, Chen Zhiyi, Cai Yao, Hu Chaochao, Qu Yanfu, Li Hong, Zhou Kaiya, Yan Jie, Li Peng

机构信息

Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China.

School of Food Science, Nanjing Xiaozhuang University, Nanjing, Jiangsu 211171, P.R. China.

出版信息

iScience. 2023 Nov 14;27(1):108445. doi: 10.1016/j.isci.2023.108445. eCollection 2024 Jan 19.

DOI:10.1016/j.isci.2023.108445
PMID:38205241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10776941/
Abstract

possesses flexible climbing and detoxification abilities under insectivorous habits. Still, the evolutionary mechanisms behind these traits remain unclarified. This study presents a chromosome-level genome, revealing that its evolutionary breakpoint regions were enriched with specific repetitive elements and defense response genes. Gene families unique to and positively selected genes are mainly enriched in immune, sensory, and nervous pathways. Expansion of bitter taste receptor type 2 primarily in insectivorous species could be associated with toxin clearance. Detox cytochrome P450 in . has undergone more birth and death processes than biosynthesis-type P450 genes. Proline, cysteine, glycine, and serine in corneous beta proteins of might influence flexibility and setae adhesiveness. Certain thermosensitive transient receptor potential channels under relaxed purifying selection or positive selection in . might enhance adaptation to climate change. This genome assembly offers insights into the adaptive evolution of gekkotans.

摘要

在食虫习性下具有灵活的攀爬和解毒能力。尽管如此，这些特征背后的进化机制仍未阐明。本研究展示了一个染色体水平的基因组，揭示其进化断点区域富含特定的重复元件和防御反应基因。特有基因家族和正选择基因主要富集于免疫、感官和神经通路。2型苦味受体主要在食虫物种中的扩张可能与毒素清除有关。[具体物种名称]中的解毒细胞色素P450比生物合成型P450基因经历了更多的产生和消亡过程。[具体物种名称]角质β蛋白中的脯氨酸、半胱氨酸、甘氨酸和丝氨酸可能影响柔韧性和刚毛粘附性。[具体物种名称]中某些处于松弛净化选择或正选择下的热敏瞬时受体电位通道可能增强对气候变化的适应性。这个基因组组装为壁虎的适应性进化提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/64f783fff16a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/79110bdd89c6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/048e2f3d3573/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/0cb9618d62ec/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/4f5409e8a71a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/8150b3774eb6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/18bdb5dd31f7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/64f783fff16a/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/79110bdd89c6/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/048e2f3d3573/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/0cb9618d62ec/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/4f5409e8a71a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/8150b3774eb6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/18bdb5dd31f7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ea2/10776941/64f783fff16a/gr7.jpg

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