Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94158, USA.
Department of Radiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Skeletal Radiol. 2024 Jul;53(7):1279-1286. doi: 10.1007/s00256-024-04565-y. Epub 2024 Jan 11.
To investigate the associations of thigh muscle and fat volumes with structural abnormalities on MRI related to knee osteoarthritis.
MRI studies of the thighs and knees from 100 individuals were randomly selected from the Osteoarthritis Initiative Cohort. Whole Organ MR Scoring (WORMS) and effusion-synovitis scoring were performed in all knee MRI. Thigh muscles, intermuscular fat, and subcutaneous fat were manually segmented in 15 consecutive MR thigh images. Radiographic Kellgren-Lawrence grades (KLG) were also obtained in all knee radiographs. Independent t-tests were used to investigate the associations between thigh muscle and fat volumes, and sex. Mixed-effects analyses were obtained to investigate the associations between thigh muscle and fat volumes, KLG, WOMAC pain score, cartilage and bone marrow WORMS, as well as effusion-synovitis scores.
Women had higher subcutaneous fat volume than men (616.82 vs. 229.13 cm, p < 0.01) and men had higher muscle volumes than women (p < 0.01). Quadriceps (coef = -2.15, p = 0.01) and vastus medialis (coef = -1.84, p = 0.03) volumes were negatively associated with the WORMS cartilage scores. Intermuscular fat volume (coef = 0.48, p = 0.01) was positively associated with WORMS bone marrow edema-like lesion (BMEL) scores. The quadriceps (coef = -0.99, p < 0.01) and hamstring (coef = -0.59, p = 0.01) volumes were negatively associated with WORMS BMEL scores. No evidence of an association was found between thigh muscle and fat volumes with KLG and effusion-synovitis grading (p > 0.05).
Increased quadriceps and hamstring volumes were negatively associated with cartilage lesion and BMEL scores while no evidence of an association was found between thigh muscle and fat volumes, and radiographic knee osteoarthritis or effusion-synovitis grading.
研究大腿肌肉和脂肪体积与与膝骨关节炎相关的 MRI 结构异常之间的关系。
从 Osteoarthritis Initiative 队列中随机选择了 100 名个体的大腿 MRI 研究。对所有膝关节 MRI 进行全器官 MR 评分（WORMS）和积液-滑膜炎评分。在 15 张连续的大腿 MR 图像中手动分割大腿肌肉、肌间脂肪和皮下脂肪。在所有膝关节 X 光片中还获得了放射学 Kellgren-Lawrence 分级（KLG）。使用独立 t 检验研究大腿肌肉和脂肪体积与性别之间的关系。采用混合效应分析研究大腿肌肉和脂肪体积与 KLG、WOMAC 疼痛评分、软骨和骨髓 WORMS 以及积液-滑膜炎评分之间的关系。
女性的皮下脂肪体积高于男性（616.82 比 229.13 cm，p < 0.01），男性的肌肉体积高于女性（p < 0.01）。股四头肌（系数=-2.15，p=0.01）和股内侧肌（系数=-1.84，p=0.03）体积与 WORMS 软骨评分呈负相关。肌间脂肪体积（系数=0.48，p=0.01）与 WORMS 骨髓水肿样病变（BMEL）评分呈正相关。股四头肌（系数=-0.99，p < 0.01）和腘绳肌（系数=-0.59，p=0.01）体积与 WORMS BMEL 评分呈负相关。大腿肌肉和脂肪体积与 KLG 和积液-滑膜炎分级之间没有关联的证据（p > 0.05）。
股四头肌和腘绳肌体积增大与软骨病变和 BMEL 评分呈负相关，而大腿肌肉和脂肪体积与放射学膝骨关节炎或积液-滑膜炎分级之间没有关联的证据。
