A photoelectrochemical aptasensing platform assembled at the heterojunction interface of CuBiS sensitized CuVO for bisphenol A.

The interaction between the sensitive interfaces of photoelectrochemical (PEC) semiconductor nanomaterials and microscopic matter creates endless potential for the efficient detection of endocrine disruptor. This work presents the development of a high-efficiency PEC aptasensor for bisphenol A (BPA) monitoring based on CuBiS sensitized CuVO nanocomposites with exceptional visible-light PEC activity. We implemented the integration of CuBiS nanosheet photosensitizer to sensitize the CuVO nanowire structure that was synthesized utilizing a facile hydrothermal approach. The band gap alignment between CuBiS and CuVO facilitated enduring PEC response yielding an efficient interfacial structure. The surface of the CuVO/CuBiS electrode was modified with BPA aptamer, enabling specific binding with BPA and precise quantification of its content. The developed aptamer sensors possess a wide detection range of 5.00 × 10 to 5.00 × 10 ng/mL, and a low detection limit of 1.60 × 10 ng/mL (at S/N = 3). After undergoing 20 testing cycles and enduring long-term storage, the sensor maintained its stability and showcased excellent repeatability and reproducibility. This study presents a promising methodology for the detection of BPA in environmental settings.