Magro A M, Rudofsky U H, Gilboa N, Seegal R
Lab Anim Sci. 1986 Dec;36(6):646-9.
The total 24 hour urinary outputs of the catecholamines norepinephrine (NE), epinephrine (E), dopamine (DA) and the DA metabolite homovanillic acid (HVA) were measured in hypertensive fawn-hooded rats and compared to the ancestral strain of normotensive Wistar rats. The hypertensive fawn-hooded rats demonstrated significantly higher urinary outputs of the catecholamines NE and DA, and of the DA metabolite HVA. Following treatment with the antihypertensive, debrisoquin sulfate, the blood pressure of the fawn-hooded rats decreased until it approached the levels observed in normotensive Wistar rats. By inhibiting sympathetic nervous activity and monoamine oxidase, the debrisoquin treatment significantly decreased the output of DA, NE and HVA but not E. The data suggest the fawn-hooded rat is a model of neurogenic hypertension which is characterized by an increased sympathetic output.
测定了高血压鹿头罩大鼠24小时尿中儿茶酚胺去甲肾上腺素（NE）、肾上腺素（E）、多巴胺（DA）及其代谢产物高香草酸（HVA）的总排出量，并与正常血压的Wistar大鼠的原始品系进行了比较。高血压鹿头罩大鼠的儿茶酚胺NE和DA以及DA代谢产物HVA的尿排出量显著更高。用降压药硫酸双肼屈嗪治疗后，鹿头罩大鼠的血压下降，直至接近正常血压Wistar大鼠的水平。通过抑制交感神经活动和单胺氧化酶，双肼屈嗪治疗显著降低了DA、NE和HVA的排出量，但未降低E的排出量。数据表明，鹿头罩大鼠是一种神经源性高血压模型，其特征是交感神经输出增加。
