Kirkbride K P
J Anal Toxicol. 1987 Jan-Feb;11(1):6-7. doi: 10.1093/jat/11.1.6.
A fatality in which diazinon was the suspected toxic agent was investigated. Samples of omental tissue, blood, and liver tissue were examined by gas chromatography and thin layer chromatography. Diazinon was found in the omentum (at a level of 5.1 mg/kg) and blood (in a trace amount), but no diazinon was found in the liver tissue. Methods are given for the extraction of diazinon from omental fat, the purification of these extracts by sweep co-distillation and fat precipitation, and for an estimation of the amount of diazinon present. It is not possible to determine whether the low level found arose from chronic occupational exposure, accidental dermal contact, or ingestion of a lethal dose.
对一例怀疑由二嗪农作为有毒物质导致的死亡病例进行了调查。通过气相色谱法和薄层色谱法对网膜组织、血液和肝脏组织样本进行了检测。在网膜中发现了二嗪农(含量为5.1毫克/千克)和血液中存在微量二嗪农,但在肝脏组织中未发现二嗪农。文中给出了从网膜脂肪中提取二嗪农、通过吹扫共蒸馏和脂肪沉淀对提取物进行纯化以及估算二嗪农含量的方法。无法确定所发现的低含量是由慢性职业暴露、意外皮肤接触还是摄入致死剂量引起的。