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罗勒色谱馏分中收缩脂质溶性成分的平滑肌。

Smooth muscle contracting lipid-soluble principles in chromatographic fractions of Ocimum gratissimum.

作者信息

Onajobi F D

出版信息

J Ethnopharmacol. 1986 Oct;18(1):3-11. doi: 10.1016/0378-8741(86)90038-3.

DOI:10.1016/0378-8741(86)90038-3
PMID:3821132
Abstract

Fractions isolated from Ocimum gratissimum leaves by lipid extraction and column- and thin-layer chromatography have been shown to contain components which contract guinea pig ileum, rat colon and raise rat mean arterial blood pressure. TLC analysis indicates that these compounds are fairly polar. Analysis of one of the components by mass spectra shows the presence of an unknown with a molecular mass of at least 353 daltons containing carbon, hydrogen, oxygen and possibly nitrogen. A tentative molecular formula, as deduced from computer analysis, is either C21H37O4 or C19H35N3O3.

摘要

通过脂质提取、柱色谱和薄层色谱从罗勒叶中分离出的馏分已显示含有能使豚鼠回肠、大鼠结肠收缩并升高大鼠平均动脉血压的成分。薄层色谱分析表明这些化合物极性相当大。通过质谱对其中一种成分进行分析,结果显示存在一种分子量至少为353道尔顿的未知物,其含有碳、氢、氧,可能还有氮。根据计算机分析推断出的暂定分子式为C21H37O4或C19H35N3O3。

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