佐帕特尔。十二。从蒙塔纳灌木中分离出的贝壳杉烯酸及其两种衍生物对人类精子的体外作用。

Zoapatle. XII. In vitro effect of kaurenoic acid isolated from Montanoa frutescens and two derivatives upon human spermatozoa.

作者信息

Valencia A, Wens A, Ponce-Monter H, Pedrón N, Gallegos A J, Quijano L, Calderón J, Gómez F, Ríos T

出版信息

J Ethnopharmacol. 1986 Oct;18(1):89-94. doi: 10.1016/0378-8741(86)90045-0.

Abstract

Zoapatle aqueous crude extract (ZACE) from Montanoa tomentosa has been used as an oral contraceptive in traditional Mexican medicine for centuries. Kaurenoic acid, as isolated from Montanoa frutescens, and the methyl esters of 15-hydroxy-dihydro-kaurenoic acid and 15-keto-dihydro-kaurenoic acid were tested in vitro on human sperm motility and viability. The estimated ED50 concentrations immobilization were 374, 126 and 58 micrograms/ml, respectively using 15 X 10(6) sperms/500 microliter. Kaurenoic acid and both of its derivatives displayed only weak to negligible capacity for killing human sperms.

摘要

几个世纪以来，来自绒毛山菊的佐帕特尔水粗提物（ZACE）在墨西哥传统医学中一直被用作口服避孕药。从灌木山菊中分离出的贝壳杉烯酸以及15-羟基-二氢贝壳杉烯酸和15-酮-二氢贝壳杉烯酸的甲酯在体外对人类精子活力和生存能力进行了测试。使用15×10⁶个精子/500微升时，估计使精子固定的半数有效浓度（ED50）分别为374、126和58微克/毫升。贝壳杉烯酸及其两种衍生物对杀死人类精子的能力仅表现出微弱到可忽略不计的效果。