Milner T E, Hoffer J A
J Neurosci Methods. 1987 Jan;19(1):37-45. doi: 10.1016/0165-0270(87)90019-7.
A method for long-term recording of electrical activity from small mammalian nerves and muscles is described. Electrodes for stimulating and recording activity were implanted on nerves and muscles subserving ankle flexion and extension in normal and dystrophic mice. Activity was monitored on a regular basis for up to 200 days following implantation. Neural compound action potentials, compound EMG potentials and twitch tension were recorded. Shortly after implantation, evoked EMG and twitch tension declined, but recovered progressively to values measured at the time of implantation and subsequently remained steady in normal mice. However, while dystrophic mice did recover, with EMG levels reaching 50-60% of the values recorded at implantation, tension eventually dropped to 10% in flexor muscles and 25% in extensors.
描述了一种用于长期记录小型哺乳动物神经和肌肉电活动的方法。将用于刺激和记录活动的电极植入正常和营养不良小鼠中负责踝关节屈伸的神经和肌肉上。植入后定期监测活动长达200天。记录神经复合动作电位、复合肌电图电位和抽搐张力。植入后不久，诱发的肌电图和抽搐张力下降，但逐渐恢复到植入时测量的值，随后在正常小鼠中保持稳定。然而，虽然营养不良小鼠确实恢复了，肌电图水平达到植入时记录值的50-60%，但张力最终在屈肌中降至10%，在伸肌中降至25%。
