Kurg T, Stinson R H, Millman B M
Muscle Nerve. 1982 Mar;5(3):238-46. doi: 10.1002/mus.880050311.
The structure of striated muscle (thick and thin filaments, filament lattice, and collagen), peripheral nerve myelin, and tendon collagen were studied in tissues from dystrophic and normal mice using small-angle x-ray diffraction. There were increases in the amount of disorganized tissue in the dystrophic mice, and the time course of the changes was monitored over the first 42 weeks of life. As the dystrophic mice became older, the contractile apparatus of the muscles appeared to atrophy, while the amount of collagen increased. In general, the molecular structure and packing appeared to remain unchanged as the disease progressed, although changes in the relative amounts and the organization of proteins were noted. In both normal and dystrophic mice, the collagen periodicity (65.7 nm) was 2% smaller when detected in muscle tissue compared with that detected in tendon tissue.
利用小角X射线衍射研究了营养不良小鼠和正常小鼠组织中的横纹肌结构（粗肌丝和细肌丝、肌丝晶格和胶原蛋白）、周围神经髓鞘以及肌腱胶原蛋白。营养不良小鼠中无组织的组织量增加，并在生命的前42周监测了变化的时间进程。随着营养不良小鼠年龄的增长，肌肉的收缩装置似乎萎缩，而胶原蛋白的量增加。一般来说，随着疾病的进展，分子结构和堆积似乎保持不变，尽管注意到了蛋白质相对含量和组织的变化。在正常小鼠和营养不良小鼠中，在肌肉组织中检测到的胶原蛋白周期性（65.7纳米）比在肌腱组织中检测到的小2%。
