Qiu Xiong, Zhang Yu, Xu Yao-Jun, Liang Zhong-Dan, Dai Xiao-Chang, Xiao Wei-Lie, Zhang Xing-Jie, Li Xiao-Li
Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650500, People's Republic of China.
Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, and School of Pharmacy, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650500, People's Republic of China.
Fitoterapia. 2024 Mar;173:105821. doi: 10.1016/j.fitote.2024.105821. Epub 2024 Jan 9.
Four new diterpenoids (1-4) and four known diterpenoids (5-8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome with an IC value of 7.75 μM. Further, the inhibitory effect of 4 was determined using immunofluorescence assays.
从泽漆全草中分离得到4个新的二萜类化合物（1-4）和4个已知的二萜类化合物（5-8）。化合物1和2是具有5/12多环系统的麻疯树型二萜类化合物，化合物3是具有5/10双环骨架的鼠李叶烷型二萜类化合物，化合物4是一类罕见的大戟属二萜类化合物，具有不寻常的5/10稠环系统。对分离得到的化合物进行了抗炎活性测试，结果表明化合物4对NLRP3炎性小体具有显著的抑制作用，IC值为7.75 μM。此外，通过免疫荧光测定法确定了化合物4的抑制作用。
