Itokawa Y
Magnesium. 1987;6(1):48-54.
To clarify the influence of thiamine deficiency or a dietary excess of thiamine on the mineral balance in magnesium-deficient animals, the following six different synthetic diets were fed to Wistar rats. Group 1: thiamine and magnesium-deficient; group 2: thiamine-deficient, magnesium-deficient; group 3: thiamine-sufficient, magnesium-deficient; group 4: thiamine-sufficient, magnesium-sufficient; group 5: thiamine excess, magnesium-deficient; group 6: thiamine excess, magnesium-sufficient. Rats were sacrificed after 4 weeks of these dietary regimens. In the magnesium-deficient groups, magnesium levels in serum, bone and heart decreased; calcium levels in serum and heart increased and, in contrast, calcium levels in bone decreased. These changes in mineral concentration seen in magnesium-deficient animals, as well as kidney weight changes, were alleviated significantly when the animals were also deficient in thiamine. It can be presumed that thiamine deficiency inhibits magnesium depletion and, consequently, the influence of magnesium deficiency is less significant in the thiamine- and magnesium-deficient animals. In regard to trace elements, the significant changes seen in magnesium-deficient rats were as follows: zinc in liver, muscle and blood increased and that in bone decreased. Copper in blood, kidney, muscle and heart increased and that in liver decreased. Iron in serum, liver, spleen and kidney increased and that in whole blood decreased.
为阐明硫胺素缺乏或饮食中硫胺素过量对镁缺乏动物矿物质平衡的影响，将以下六种不同的合成饲料喂给Wistar大鼠。第1组：硫胺素和镁缺乏；第2组：硫胺素缺乏、镁缺乏；第3组：硫胺素充足、镁缺乏；第4组：硫胺素充足、镁充足；第5组：硫胺素过量、镁缺乏；第6组：硫胺素过量、镁充足。在这些饮食方案实施4周后处死大鼠。在镁缺乏组中，血清、骨骼和心脏中的镁水平降低；血清和心脏中的钙水平升高，相反，骨骼中的钙水平降低。当动物也缺乏硫胺素时，镁缺乏动物中观察到的这些矿物质浓度变化以及肾脏重量变化得到显著缓解。可以推测，硫胺素缺乏会抑制镁的消耗，因此，在硫胺素和镁缺乏的动物中，镁缺乏的影响不太显著。关于微量元素，镁缺乏大鼠中观察到的显著变化如下：肝脏、肌肉和血液中的锌增加，骨骼中的锌减少。血液、肾脏、肌肉和心脏中的铜增加，肝脏中的铜减少。血清、肝脏、脾脏和肾脏中的铁增加，全血中的铁减少。
