Fleming J L, Ahlquist D A, McGill D B, Zinsmeister A R, Ellefson R D, Schwartz S
Mayo Clin Proc. 1987 Mar;62(3):159-63. doi: 10.1016/s0025-6196(12)62437-9.
We sought to determine the short-term effects of use of aspirin and ethanol on fecal occult blood levels measured with the HemoQuant assay. A factorial design was used to study 68 healthy volunteers randomized to receive various doses of aspirin, ethanol, or a combination of both for either 1 or 3 days. Fecal hemoglobin concentrations were measured before and after drug ingestions. Moderate quantities of ethanol (300 ml of 5% or 30 ml of 50% three times nightly) did not cause significant fecal blood elevation unless aspirin was administered concomitantly (P = 0.05). High-dose aspirin alone, 975 mg three times daily, induced abnormal blood loss (P less than 0.01). The highest HemoQuant levels were usually noted after concomitant administration of aspirin and ethanol at maximal doses for 3 days (P less than 0.005), some HemoQuant levels approaching 5 times the normal value. We conclude that, in a short-term analysis, social consumption of ethanol is unlikely to interfere with fecal blood testing but therapeutic doses of aspirin will.
我们试图确定使用阿司匹林和乙醇对采用血红素定量分析法测得的粪便潜血水平的短期影响。采用析因设计对68名健康志愿者进行研究，这些志愿者被随机分组，接受不同剂量的阿司匹林、乙醇或两者的组合，为期1天或3天。在摄入药物前后测量粪便血红蛋白浓度。适量的乙醇（每晚三次，每次300毫升5%的乙醇或30毫升50%的乙醇）不会导致粪便潜血显著升高，除非同时服用阿司匹林（P = 0.05）。单独使用高剂量阿司匹林，即每日三次，每次975毫克，会导致异常失血（P < 0.01）。通常在同时给予最大剂量的阿司匹林和乙醇3天后，血红素定量水平最高（P < 0.005），一些血红素定量水平接近正常值的5倍。我们得出结论，在短期分析中，社交性饮酒不太可能干扰粪便潜血检测，但治疗剂量的阿司匹林会。
