St. Carolus Hospital, Jakarta, Indonesia.
Acta Med Indones. 2023 Oct;55(4):455-459.
Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a unique disorder that manifests as an acute myocardial infarction clinically without overt coronary arteries obstruction on angiography. Herein, we report a 17-year-old male presented with a chest pain occurring 3 hours before admission and fever lasting for 2 days. Electrocardiogram examination showed ST elevation in lead II, III, aVF and V3-V6. Laboratory tests results showed a normal leukocyte level of 9850/µL, an elevated troponin of 3.55 ng/mL and an elevated quantitative CRP of 46 mg/L. Coronary angiography performed, indicating 20-30% stenosis of the left anterior descending artery, left circumflex artery and right coronary artery, whereas in typical acute myocardial injury, angiography shows >50% coronary stenosis. Additional cardiac MRI examination showed a fulfillment of Lake Louis Criteria for myocarditis, with further findings of acute myocardial edema in the lateral wall of left ventricle, with left ventricle ejection fraction of 59.73%. As researchers are still working on the definition of MINOCA, present knowledge of the causes, pathophysiology, clinical features, or specific phenotypes of MINOCA is also limited. A stepwise diagnostic approach is needed to diagnose MINOCA, with subsequent differential diagnosis exclusion.
非阻塞性冠状动脉心肌梗死(MINOCA)是一种独特的疾病,表现为临床上急性心肌梗死,而冠状动脉造影未见明显阻塞。在此,我们报告了一例 17 岁男性,胸痛发作于入院前 3 小时,发热持续 2 天。心电图检查显示 II、III、aVF 和 V3-V6 导联 ST 段抬高。实验室检查结果显示白细胞水平正常为 9850/µL,肌钙蛋白升高至 3.55ng/mL,C 反应蛋白定量升高至 46mg/L。进行冠状动脉造影检查,显示左前降支、左旋支和右冠状动脉狭窄程度为 20-30%,而在典型的急性心肌损伤中,造影显示 >50%的冠状动脉狭窄。此外,心脏 MRI 检查显示符合心肌炎的路易斯湖标准,进一步发现左心室侧壁急性心肌水肿,左心室射血分数为 59.73%。由于研究人员仍在研究 MINOCA 的定义,目前对 MINOCA 的病因、病理生理学、临床特征或特定表型的了解也有限。需要采用逐步诊断方法来诊断 MINOCA,并进行后续鉴别诊断排除。