Jangir Hemlata, Balmuchu Govinda, Mylapalli Jhansi Lakshmi, Subramanian Arulselvi, Lalwani Sanjeev
All India Institute of Medical Sciences, Jai Prakash Narayan Apex Trauma Centre, Department of Laboratory Medicine, New Delhi, India.
All India Institute of Medical Sciences, Jai Prakash Narayan Apex Trauma Centre, Department of Forensic Pathology and Molecular DNA, New Delhi, India.
Autops Case Rep. 2024 Jan 8;13:e2023465. doi: 10.4322/acr.2023.465. eCollection 2023.
Toxic leukoencephalopathy (TLE) is a rare neurological debilitating and fatal condition. It has been previously associated with exposure to leukotoxic offenders such as chemotherapy, cranial radiation, certain drugs, and environmental factors. Currently, it is a commoner white matter syndrome resulting from increased substance abuse, classically by inhaled heroin and other opioids. Herein, we report a case of fatal TLE unveiled in an autopsy of a drug abuser. A 24-year-old male was found dead on the roadside. A day before, he was located in a state of delirium. In this case, the autopsy findings and histopathology characteristics of cerebral cortex involvement particularly directed to speculate the heroine as the principal offender.
中毒性白质脑病（TLE）是一种罕见的、使人衰弱并可致命的神经系统疾病。此前它一直与接触如化疗、颅脑放疗、某些药物及环境因素等白质毒性物质有关。目前，它是因药物滥用增加导致的一种较为常见的白质综合征，典型的是吸入海洛因及其他阿片类药物所致。在此，我们报告一例在一名药物滥用者尸检中发现的致命性TLE病例。一名24岁男性被发现死于路边。前一天，他处于谵妄状态。在该病例中，尸检结果及大脑皮质受累的组织病理学特征尤其提示推测海洛因是主要致病因素。
