Department of Biomedical Engineering, University of Melbourne, Melbourne 3010, Australia.
J Neural Eng. 2024 Jan 23;21(1). doi: 10.1088/1741-2552/ad1e23.
. Chronopotentiometric voltage transients (VTs) are used to assess the performance of bionic electrodes. The data obtained from VTs are used to define the safe operating conditions of clinical devices. Various approaches to analysing VTs have been reported, and a number of limitations in the accuracy of the measurements in relation to electrode size have been noted previously.. The impact of electronic hardware and electrode configuration on VTs is discussed.. The slew rate, rise time, sample time, minimum pulse length and waveform averaging characteristics of the electronic hardware, and electrode configuration will impact on VT measurement accuracy. Subsequently, activation and polarisation voltage measurements, and the definition of safe stimulation levels can be affected by the electronic hardware and electrode configuration.. This article has identified some limitations in the previous literature related to the measurement and reporting of VTs and subsequent analysis of access and polarisation voltages. Furthermore, the commonly used Shannon plot used to define safe stimulation protocols does not correct for uncompensated resistance, account for electrode roughness or changes in electrode configuration. The creation of a safe stimulation plot which has been corrected for uncompensated resistance would generate more widely applicable stimulation guidelines for clinical devices used in different anatomical locations such as endovascular neural interfaces.
. 暂态电流电压（VTs）被用于评估仿生电极的性能。从 VTs 获得的数据被用于定义临床设备的安全操作条件。已经报道了各种分析 VTs 的方法，并且之前已经注意到了与电极尺寸相关的测量精度的一些限制。. 讨论了电子硬件和电极配置对 VTs 的影响。电子硬件的上升时间、采样时间、最小脉冲长度和波形平均特性以及电极配置会影响 VT 测量精度。随后，激活和极化电压测量以及安全刺激水平的定义可能会受到电子硬件和电极配置的影响。. 本文已经确定了之前文献中与 VTs 的测量和报告以及后续访问和极化电压分析相关的一些限制。此外，通常用于定义安全刺激方案的 Shannon 图没有校正未补偿电阻，也没有考虑电极粗糙度或电极配置的变化。校正了未补偿电阻的安全刺激图的创建将为在不同解剖位置（如血管内神经界面）使用的临床设备生成更广泛适用的刺激指南。
