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多潘立酮经肠外和直肠给药治疗儿童严重呕吐的多中心试点研究。

A multicentre pilot study of parenteral and rectal administration of domperidone in the treatment of severe vomiting in children.

作者信息

Clara R, Van Hollebeke J, Heck E

出版信息

Postgrad Med J. 1979;55 Suppl 1:43-4.

PMID:382155
Abstract

A small scale pilot study among 41 children with severe vomiting, showed that a single administration of domperidone either intravenously, intramuscularly or rectally, effectively controlled the symptom within 3 hours in 36 (88%) patients. The excellent results together with the safety of this new drug indicate its potential value in these patients.

摘要

一项针对41名严重呕吐儿童的小规模试点研究表明，静脉注射、肌肉注射或直肠给药一次多潘立酮，可使36名（88%）患者在3小时内有效控制症状。这种新药的出色效果及其安全性表明了其在这些患者中的潜在价值。

相似文献

1
A multicentre pilot study of parenteral and rectal administration of domperidone in the treatment of severe vomiting in children.多潘立酮经肠外和直肠给药治疗儿童严重呕吐的多中心试点研究。
Postgrad Med J. 1979;55 Suppl 1:43-4.
2
A double-blind comparison of domperidone and metoclopramide suppositories in the treatment of nausea and vomiting in children.多潘立酮与甲氧氯普胺栓剂治疗儿童恶心呕吐的双盲对照研究。
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Domperidone drops in the symptomatic treatment of chronic paediatric vomiting and regurgitation. A comparison with metoclopramide.
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Biomedicine. 1978 Nov;29(7):242-4.
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The efficacy of Domperidone (R 33812) in the treatment of postoperative vomiting. A double-blind study with a placebo.多潘立酮（R 33812）治疗术后呕吐的疗效。一项与安慰剂对照的双盲研究。
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Domperidone in the prevention of post-operative nausea and vomiting.
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Preliminary report of domperidone (R 33182), a new antiemetic compound. A pilot study.新型止吐化合物多潘立酮（R 33182）的初步报告。一项试点研究。
Acta Anaesthesiol Belg. 1977;28(4):245-50.
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Postoperative vomiting treated with domperidone. A double-blind comparison with metoclopramide and a placebo.多潘立酮治疗术后呕吐。与甲氧氯普胺和安慰剂的双盲对照研究。
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引用本文的文献

1
On the pharmacokinetics of domperidone in animals and man. IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration.多潘立酮在动物和人体中的药代动力学。IV. 静脉注射多潘立酮的药代动力学及其在肌肉注射、口服和直肠给药后的人体生物利用度。
Eur J Drug Metab Pharmacokinet. 1981;6(1):61-70. doi: 10.1007/BF03189516.
2
Domperidone as an antiemetic in paediatric oncology.多潘立酮作为儿科肿瘤学中的一种止吐药。
Cancer Chemother Pharmacol. 1981;6(2):147-9. doi: 10.1007/BF00262334.
3
Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.
多潘立酮。对其药理活性、药代动力学以及在慢性消化不良症状治疗和作为止吐药方面的治疗效果的综述。
Drugs. 1982 Nov;24(5):360-400. doi: 10.2165/00003495-198224050-00002.